Current opinion in allergy and clinical immunology · 2009
Drug skin metabolites and allergic drug reactions.
СтатьяПоддержка исследования: вне правительства СШАОбзорНазвание и аннотация: Перевод в очереди
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Merk Hans F
Аннотация
PURPOSE OF REVIEW: Presentation of recent studies about xenobiotica metabolism of the skin and its impact on drug-allergic reactions.
RECENT FINDINGS: The skin possesses not only multiple cytochrome P450 isoenzymes but also influx and efflux transporter proteins. The pattern of cytochrome P450 isoenzymes in the skin differs from the pattern in the liver. Studies on the role of this metabolism in drug-induced hypersensitivity have mainly focused on sulphonamides, anticonvulsants, diclofenac and nevirapine. Studies with the contact sensitizer carvoxime provided evidence for the decisive role of xenobiotica metabolism in antigen-presenting cells.
SUMMARY: The skin is a major target organ for allergic drug reactions that may be explained by its different barrier functions including immune system and the armamentarium of xenobiotica-metabolizing enzymes.
RECENT FINDINGS: The skin possesses not only multiple cytochrome P450 isoenzymes but also influx and efflux transporter proteins. The pattern of cytochrome P450 isoenzymes in the skin differs from the pattern in the liver. Studies on the role of this metabolism in drug-induced hypersensitivity have mainly focused on sulphonamides, anticonvulsants, diclofenac and nevirapine. Studies with the contact sensitizer carvoxime provided evidence for the decisive role of xenobiotica metabolism in antigen-presenting cells.
SUMMARY: The skin is a major target organ for allergic drug reactions that may be explained by its different barrier functions including immune system and the armamentarium of xenobiotica-metabolizing enzymes.