Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2005
Preliminary results after implantation of four AlphaCor artificial corneas.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Bleckmann H, Holak S
Аннотация
PURPOSE: The purpose was to evaluate the validity of implantation of the artificial cornea (AlphaCor) in human corneas considered too high risk for penetrating keratoplasty with donor tissue.
METHODS: Four keratoprostheses, made from poly(2-hydroxyethyl methacrylate) (PHEMA) with a porous skirt and a transparent optical part, were implanted into the cornea of four patients. Keratocytes invading the skirt provide a watertight fixation with the scarred corneal tissue. Deep to the clear optical part, the posterior corneal lamella was excised to a diameter of 3.5 mm before the device was implanted, and the anterior lamella was trephined similarly 3 months after AlphaCor implantation.
RESULTS: The eyes selected to receive an artificial cornea had significant neovascularisation, and 0-3 previous failed grafts. Follow-up for 6 months revealed best visual acuity between 20/400 and 20/50. Factors limiting the visual acuity outcome were optic atrophy and age-related macular disease. One patient underwent an extracapsular cataract extraction after the device was implanted, as a senile cataract was then noted. One complication occurred, a central corneal stromal melt, which was managed by covering with a 9-mm donor lamella.
CONCLUSION: The flexible device AlphaCor may provide a substitute for donor corneal tissue in desperate cases. Advantages include the simple implantation technique, which avoids trauma to the surrounding structures. Visual acuity results may be limited by pre-existing pathology, but it appears that a patient's visual potential can be achieved. Further follow-up to exclude long-term complications is required.
METHODS: Four keratoprostheses, made from poly(2-hydroxyethyl methacrylate) (PHEMA) with a porous skirt and a transparent optical part, were implanted into the cornea of four patients. Keratocytes invading the skirt provide a watertight fixation with the scarred corneal tissue. Deep to the clear optical part, the posterior corneal lamella was excised to a diameter of 3.5 mm before the device was implanted, and the anterior lamella was trephined similarly 3 months after AlphaCor implantation.
RESULTS: The eyes selected to receive an artificial cornea had significant neovascularisation, and 0-3 previous failed grafts. Follow-up for 6 months revealed best visual acuity between 20/400 and 20/50. Factors limiting the visual acuity outcome were optic atrophy and age-related macular disease. One patient underwent an extracapsular cataract extraction after the device was implanted, as a senile cataract was then noted. One complication occurred, a central corneal stromal melt, which was managed by covering with a 9-mm donor lamella.
CONCLUSION: The flexible device AlphaCor may provide a substitute for donor corneal tissue in desperate cases. Advantages include the simple implantation technique, which avoids trauma to the surrounding structures. Visual acuity results may be limited by pre-existing pathology, but it appears that a patient's visual potential can be achieved. Further follow-up to exclude long-term complications is required.