Vestnik oftalmologii · 2026
[Evaluation of the inflammatory response after implantation of different types of phakic intraocular lenses in high myopia].
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Kamalov Z S, Kamilov Kh M, Yusupov A F, Zaynutdinov N N
Аннотация
UNLABELLED: High myopia is one of the main causes of reversible vision loss worldwide among the working-age population. Despite the widespread use of phakic intraocular lenses (PIOLs) for correction, immunological changes in the aqueous humor before and after implantation remain insufficiently studied.
OBJECTIVE: The study aimed to assess and compare cytokine levels in the aqueous humor before and after implantation of collamer-based and acrylic-based PIOLs in patients with high myopia.
MATERIAL AND METHODS: The study included 58 patients (103 eyes) with high myopia scheduled for PIOL implantation. The main group (A) consisted of 36 patients (68 eyes) who received collamer-based PIOLs. The comparison group (B) comprised 22 patients (35 eyes) who received acrylic-based PIOLs. The control group included 20 patients (20 eyes) with emmetropia. Cytokine levels of IL-6, TNF-α, and TGF-β2 were studied only in 18 patients (30 eyes) using solid-phase enzyme-linked immunosorbent assay with special reagents.
RESULTS: After implantation of different types of PIOLs, all patients included in the study achieved the desired outcome: residual refractive error (0.75±0.5 D) and visual acuity (0.85±0.17) remained stable during the 24-month postoperative period. Before PIOL implantation, patients with high myopia showed a statistically significant increase in IL-6 concentration - more than 2.5-fold (9.51±0.52 pg/ml vs 3.82±0.26 pg/ml in the control group) (p<0.001). The TNF-α level increased almost 1.8-fold (9.98±0.53 pg/ml vs 5.63±0.42 pg/ml in the control group) (p<0.001). In the main group, the TGF-β2 level was 15.99±1.09 pg/ml, which was 4.1- times higher than the control values (3.88±0.26 pg/ml) (p<0.001).
CONCLUSION: PIOL implantation in high myopia is an effective, safe, and reliable correction method associated with marked changes in the local cytokine profile. Collamer lenses induce a less intense inflammatory response and a more active remodeling reaction compared with acrylic lenses.
OBJECTIVE: The study aimed to assess and compare cytokine levels in the aqueous humor before and after implantation of collamer-based and acrylic-based PIOLs in patients with high myopia.
MATERIAL AND METHODS: The study included 58 patients (103 eyes) with high myopia scheduled for PIOL implantation. The main group (A) consisted of 36 patients (68 eyes) who received collamer-based PIOLs. The comparison group (B) comprised 22 patients (35 eyes) who received acrylic-based PIOLs. The control group included 20 patients (20 eyes) with emmetropia. Cytokine levels of IL-6, TNF-α, and TGF-β2 were studied only in 18 patients (30 eyes) using solid-phase enzyme-linked immunosorbent assay with special reagents.
RESULTS: After implantation of different types of PIOLs, all patients included in the study achieved the desired outcome: residual refractive error (0.75±0.5 D) and visual acuity (0.85±0.17) remained stable during the 24-month postoperative period. Before PIOL implantation, patients with high myopia showed a statistically significant increase in IL-6 concentration - more than 2.5-fold (9.51±0.52 pg/ml vs 3.82±0.26 pg/ml in the control group) (p<0.001). The TNF-α level increased almost 1.8-fold (9.98±0.53 pg/ml vs 5.63±0.42 pg/ml in the control group) (p<0.001). In the main group, the TGF-β2 level was 15.99±1.09 pg/ml, which was 4.1- times higher than the control values (3.88±0.26 pg/ml) (p<0.001).
CONCLUSION: PIOL implantation in high myopia is an effective, safe, and reliable correction method associated with marked changes in the local cytokine profile. Collamer lenses induce a less intense inflammatory response and a more active remodeling reaction compared with acrylic lenses.