Optics express · 2026
Target enhanced and color preserved 3D reconstruction based on a multi-wavelength polarization line-structured light.
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Wang Weiran, Zhong Yangwan, Wang Feng, Luo Jing, Xiao Qingsheng, Xiao Shilei
Аннотация
INTRODUCTION: Although resection surgery is a curative treatment for hepatocellular carcinoma (HCC), high HCC recurrence leads to poor patient survival. Chronic hepatitis B virus (HBV) infection is an important risk factor for HCC. Deletion mutation in HBV pre-S2 gene results in expression of pre-S2 mutant oncoprotein and represents an independent prognostic biomarker for HCC recurrence. MicroRNAs (miRNAs) are small non-coding RNAs that play key roles in HBV-related HCC.
METHODS: This study aimed to identify the miRNAs whose expression levels in tumor tissues were correlated with pre-S2 gene deletion mutation and post-resection HCC recurrence and investigate their potential in combination with pre-S2 gene deletion mutation to predict HCC recurrence in a retrospective cohort of patients.
RESULTS: The results showed that the expression level of miR-369-3p was decreased in tumor tissues of patients with pre-S2 gene deletion mutation or HCC recurrence. miR-369-3p was identified as a prognostic biomarker for HCC recurrence. Patients with pre-S2 gene deletion mutation combined with a low level of miR-369-3p had a higher risk of HCC recurrence than patients with either one or none of these two biomarkers. The combination of pre-S2 gene deletion mutation and miR-369-3p expression level showed a greater prognostic potential for HCC recurrence than either biomarker alone.
CONCLUSION: Collectively, miR-369-3p held exploratory promise in serving as a combination biomarker with pre-S2 gene deletion mutation to provide a better potential in predicting HBV-related HCC recurrence after curative surgical resection.
METHODS: This study aimed to identify the miRNAs whose expression levels in tumor tissues were correlated with pre-S2 gene deletion mutation and post-resection HCC recurrence and investigate their potential in combination with pre-S2 gene deletion mutation to predict HCC recurrence in a retrospective cohort of patients.
RESULTS: The results showed that the expression level of miR-369-3p was decreased in tumor tissues of patients with pre-S2 gene deletion mutation or HCC recurrence. miR-369-3p was identified as a prognostic biomarker for HCC recurrence. Patients with pre-S2 gene deletion mutation combined with a low level of miR-369-3p had a higher risk of HCC recurrence than patients with either one or none of these two biomarkers. The combination of pre-S2 gene deletion mutation and miR-369-3p expression level showed a greater prognostic potential for HCC recurrence than either biomarker alone.
CONCLUSION: Collectively, miR-369-3p held exploratory promise in serving as a combination biomarker with pre-S2 gene deletion mutation to provide a better potential in predicting HBV-related HCC recurrence after curative surgical resection.