Dupuytren's disease: a state-of-the-art review.

Dupuytren's disease (DD) is a common chronic hand condition that affects patients worldwide. Presenting with palpable fibrotic nodules, the disease leads to progressive and irreversible flexion of digits, affecting patients' hand function, impairing daily activities and potentially reducing the quality of life. Management techniques are primarily corrective and do not address the biological mechanisms underlying disease pathogenesis and progression. While non-surgical interventions are used to manage early stage DD, advanced disease requires surgical correction. This review provides an overview of the epidemiology and risk factors associated with DD and the latest research on the mechanisms underlying its progression. It summarizes the main non-surgical and surgical corrective options currently available and discusses the future of early stage DD treatment.