Robust Hidden Markov Model based intelligent blood vessel detection of fundus images.

In this paper, we consider the challenging problem of detecting retinal vessel networks. Precise detection of retinal vessel networks is vital for accurate eye disease diagnosis. Most of the blood vessel tracking techniques may not properly track vessels in presence of vessels' occlusion. Owing to problem in sensor resolution or acquisition of fundus images, it is possible that some part of vessel may occlude. In this scenario, it becomes a challenging task to accurately trace these vital vessels. For this purpose, we have proposed a new robust and intelligent retinal vessel detection technique on Hidden Markov Model. The proposed model is able to successfully track vessels in the presence of occlusion. The effectiveness of the proposed technique is evaluated on publically available standard DRIVE dataset of the fundus images. The experiments show that the proposed technique not only outperforms the other state of the art methodologies of retinal blood vessels segmentation, but it is also capable of accurate occlusion handling in retinal vessel networks. The proposed technique offers better average classification accuracy, sensitivity, specificity, and area under the curve (AUC) of 95.7%, 81.0%, 97.0%, and 90.0% respectively, which shows the usefulness of the proposed technique.