Clinical Course of Iris Retraction Syndrome Associated With Rhegmatogenous Retinal Detachment: A Report of Three Cases.

This report describes three cases of iris retraction syndrome (IRS) associated with long-standing rhegmatogenous retinal detachment (RRD), all presenting with hypotony, abnormally deep anterior chambers, and ciliary body detachment, often accompanied by dense cataracts and uveitis-like findings that initially obscured the underlying pathology. In each case, anti-inflammatory therapy led to partial resolution of anterior segment abnormalities, subsequently revealing RRD that required pars plana vitrectomy with or without combined cataract surgery. Postoperatively, most cases maintained stable IOP, although one developed secondary ocular hypertension necessitating glaucoma therapy. These cases highlight that IRS can mask its primary cause; careful evaluation for RRD or other causes is warranted when posterior iris bowing is observed in hypotonic eyes, and long-term IOP monitoring remains important even after successful treatment of the underlying pathology.