Frontiers in oncology · 2026
Non-pharmacological therapies for breast cancer-related lymphedema: a systematic review and network meta-analysis based on randomized controlled trials.
СтатьяСистематический обзорНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Fang Ningning, Xin Hong, Wu Mengmeng
Аннотация
BACKGROUND: Approximately 30% of breast cancer patients develop lymphedema after axillary surgery or radiotherapy, which impairs their quality of life and exacerbates symptoms. Non-pharmacological therapies show efficacy for breast cancer-related lymphedema (BCRL), but the optimal approach remains unclear.
OBJECTIVE: This study aimed to determine the most effective non-pharmacological interventions for BCRL by comparing limb volume, circumference, and pain outcomes.
METHODS: Cochrane, Embase, PubMed, and Web of Science databases were searched from inception to August 12, 2025, with key terms on BCRL, breast cancer, lymphedema, and non-pharmacological therapies. Cochrane RoB2 was used to assess the risk of bias. Network meta-analyses were conducted using R 4.4.1. SUCRA values were calculated to rank interventions.
RESULTS: Seventeen studies (754 patients) were included. In terms of reducing limb volume, weight reduction ranked highest (SMD: -1.2, 95% CrI [-2.1, -0.22]; SUCRA = 82.21%), followed by virtual reality (VR), exercise combined with compression therapy, and exercise therapy. For pain relief, VR-based training ranked highest (SMD: -3.7, 95% CrI [-4.5, -3.0]; SUCRA = 99.65%). However, given the sparse network topology and the limited number of included studies, these rankings should be interpreted with caution. Regarding limb circumference, the currently available evidence (which included only 3 studies with limited statistical power) did not detect any statistically significant differences among the interventions.
CONCLUSIONS: Among non-pharmacological treatments for BCRL, weight reduction was most effective in improving limb volume, while VR-based training was most effective in improving pain scores in the edematous limb.
SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/prospero/, identifier CRD420250654557.
OBJECTIVE: This study aimed to determine the most effective non-pharmacological interventions for BCRL by comparing limb volume, circumference, and pain outcomes.
METHODS: Cochrane, Embase, PubMed, and Web of Science databases were searched from inception to August 12, 2025, with key terms on BCRL, breast cancer, lymphedema, and non-pharmacological therapies. Cochrane RoB2 was used to assess the risk of bias. Network meta-analyses were conducted using R 4.4.1. SUCRA values were calculated to rank interventions.
RESULTS: Seventeen studies (754 patients) were included. In terms of reducing limb volume, weight reduction ranked highest (SMD: -1.2, 95% CrI [-2.1, -0.22]; SUCRA = 82.21%), followed by virtual reality (VR), exercise combined with compression therapy, and exercise therapy. For pain relief, VR-based training ranked highest (SMD: -3.7, 95% CrI [-4.5, -3.0]; SUCRA = 99.65%). However, given the sparse network topology and the limited number of included studies, these rankings should be interpreted with caution. Regarding limb circumference, the currently available evidence (which included only 3 studies with limited statistical power) did not detect any statistically significant differences among the interventions.
CONCLUSIONS: Among non-pharmacological treatments for BCRL, weight reduction was most effective in improving limb volume, while VR-based training was most effective in improving pain scores in the edematous limb.
SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/prospero/, identifier CRD420250654557.