Acta oto-laryngologica · 2026
Research progress of biomaterial conduit in repairing facial nerve injury.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Li Yunuo, Gao Li, Xie Miao, Yang Rui, Duan Maoli, Lu Ling
Аннотация
BACKGROUND: Facial nerve injury poses a major challenge in otolaryngology, where functional restoration remains critical. As autologous nerve grafts present limitations, biomaterial-based nerve guidance conduits (NGCs) offer a viable alternative for bridging nerve defects.
OBJECTIVE: This review covers the updated research results in NGCs in the past five years.
MATERIAL AND METHODS: Recent publications were critically reviewed.
RESULTS: This review highlights recent progress in advanced biomaterials and manufacturing methods for NGC fabrication, with emphasis on functionalization strategies-such as incorporation of stem cells, bioactive factors, topographic cues, and electrical stimulation-to synergistically enhance axonal regrowth, myelination, and functional recovery. Overall, biomaterial conduits are advancing as multifunctional integrated systems, showing strong translational potential for precision repair of facial nerves.
CONCLUSION AND SIGNIFICANCE: Over the past five years, research emphasis in this field has shifted toward developing composite conduit materials capable of actively guiding neural regeneration through the incorporation of biochemical and biological cues.
OBJECTIVE: This review covers the updated research results in NGCs in the past five years.
MATERIAL AND METHODS: Recent publications were critically reviewed.
RESULTS: This review highlights recent progress in advanced biomaterials and manufacturing methods for NGC fabrication, with emphasis on functionalization strategies-such as incorporation of stem cells, bioactive factors, topographic cues, and electrical stimulation-to synergistically enhance axonal regrowth, myelination, and functional recovery. Overall, biomaterial conduits are advancing as multifunctional integrated systems, showing strong translational potential for precision repair of facial nerves.
CONCLUSION AND SIGNIFICANCE: Over the past five years, research emphasis in this field has shifted toward developing composite conduit materials capable of actively guiding neural regeneration through the incorporation of biochemical and biological cues.