Veterinary surgery : VS · 2025
Saline-based modified del Nido cardioplegia versus multidose St. Thomas cardioplegia in canine mitral valve repair: A randomized controlled trial.
СтатьяRandomized Controlled Trial, VeterinaryНазвание и аннотация: Перевод в очереди
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Kurogochi Kentaro, Takahashi Arane, Nii Yasuyuki, Chen Ayaka, Nishiyama Masako, Furusato Shimon, Sugiya Hiroshi, Uechi Masami
Аннотация
OBJECTIVE: To compare the utility of a saline-based modified del Nido (mDN) cardioplegia solution with a conventional institutional technique (multidose St. Thomas blood cardioplegia) for mitral valve repair (MVR) in dogs.
STUDY DESIGN: Prospective, randomized, open-label trial.
ANIMALS: Forty client-owned dogs with myxomatous mitral valve disease (stage B2 and C) eligible for MVR were divided into control and modified mDN groups.
METHODS: Cardioplegia was induced in the control group using 50% blood containing St. Thomas solution every 10 min. In the mDN group, a cardioplegia solution containing 20% blood was administered once or when required. As the primary outcome, serum cardiac troponin I levels were compared 12 h postoperatively between the groups. The other clinical findings were evaluated as secondary outcomes.
RESULTS: Troponin levels 12 h after surgery were a median of 27.8 ng/mL (interquartile range, 15.1-43.2) in the control group and 19.4 ng/mL (15.2-33.6) in the mDN group (p = .478). The sinus rhythm recovery time following aortic cross-clamp removal was 362 s (103-995) in the control group and 60 s (44-605) in the mDN group (p = .027). The total amount of crystalloid cardioplegia solution required was 12.6 mL/kg (11.3-15.0) in the control group and 23.6 mL/kg (18.0-35.1) in the mDN group (p < .001).
CONCLUSION: Cardiac troponin I levels did not show differences between the groups. The saline-based mDN cardioplegia facilitated earlier sinus rhythm recovery.
CLINICAL SIGNIFICANCE: Saline-based mDN cardioplegia may be a viable alternative for canine MVR.
STUDY DESIGN: Prospective, randomized, open-label trial.
ANIMALS: Forty client-owned dogs with myxomatous mitral valve disease (stage B2 and C) eligible for MVR were divided into control and modified mDN groups.
METHODS: Cardioplegia was induced in the control group using 50% blood containing St. Thomas solution every 10 min. In the mDN group, a cardioplegia solution containing 20% blood was administered once or when required. As the primary outcome, serum cardiac troponin I levels were compared 12 h postoperatively between the groups. The other clinical findings were evaluated as secondary outcomes.
RESULTS: Troponin levels 12 h after surgery were a median of 27.8 ng/mL (interquartile range, 15.1-43.2) in the control group and 19.4 ng/mL (15.2-33.6) in the mDN group (p = .478). The sinus rhythm recovery time following aortic cross-clamp removal was 362 s (103-995) in the control group and 60 s (44-605) in the mDN group (p = .027). The total amount of crystalloid cardioplegia solution required was 12.6 mL/kg (11.3-15.0) in the control group and 23.6 mL/kg (18.0-35.1) in the mDN group (p < .001).
CONCLUSION: Cardiac troponin I levels did not show differences between the groups. The saline-based mDN cardioplegia facilitated earlier sinus rhythm recovery.
CLINICAL SIGNIFICANCE: Saline-based mDN cardioplegia may be a viable alternative for canine MVR.