Effects of Coriandrum sativum L. (coriander) essential oil on Candida spp. in oral infection: Scoping review.

OBJECTIVE

This is an scoping review aimed at mapping the effects of Coriandrum sativum essential oil (CSEO) on oral fungal infection caused by Candida.

DESIGN

Scoping review was conducted according to the methodology of the Joanna Briggs Institute and guided by the research question: What are the effects of CSEO on Candida in oral infection? Searches were performed in the following databases: SciELO, MEDLINE/PubMed, Web of Science, Scopus, Cochrane Library, the CAPES Journal Portal and Google Scholar. Publications in Portuguese, English, and Spanish were included, with no restrictions on date or population. MeSH/DeCS descriptors were used. Study inclusion and review development followed the PRISMA-ScR checklist.

RESULTS

Out of the 245 studies identified, 30 were included. The findings revealed that the plant part, extraction method, environmental conditions, and genetic factors influenced variations in the phytochemical profile. Linalool was the major component extracted from seeds, fruits and flowers, while 1-decanol, decanal, 2E-decenol were predominant in leaf extracts. Although no clinical trial and in vivo experimental studies were found, in vitro experimental studies were identified, which demonstrated significant antioxidant, anti-inflammatory and antifungal activities, both against resistant strains and biofilms, in addition to synergistic effects with conventional antifungals and low to moderate toxicity.

CONCLUSION

This review identified significant effects of CSEO against Candida, suggesting it is a promising candidate or potential adjuvant. However, further clinical and in vivo validation, with methodological standardization, to assess the safety, tolerability, and efficacy of this oil.