Molecular biology reports · 2026
Biological pathways related to mirna-125a-5p in behavioral variant of frontotemporal dementia.
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Pereira Jessica Diniz, Silva Leticia Moreira, Ozawa Mhai, Tosatti Jéssica Abdo Gonçalves, Lima Stephanny Pinto Oliveira, Silva Isabela Resende, Jeunon Vinicius Ribeiro, das Graças Carvalho Maria, de Paula França Resende Elisa, de Souza Leonardo Cruz, Caramelli Paulo, Gomes Karina Braga
Аннотация
BACKGROUND: Frontotemporal dementia (FTD) comprises a group of neurodegenerative disorders that lead to progressive changes in language, behavior, personality, and movement. Accounting for approximately 60% of cases, the behavioral variant (bvFTD) represents the most common clinical presentation of FTD. MicroRNAs (miRNAs) are small non-coding RNAs involved in gene regulation and are expressed in various biological fluids. Considering bvFTD as an inflammatory disorder, this study investigated the expression of inflammation-related miRNAs in individuals with bvFTD compared with age- and sex-matched cognitively healthy controls.
METHODS: Twenty patients with bvFTD and 20 cognitively healthy controls, matched for age and sex, were included in the study. Serum levels of miRNA-30c-5p and miRNA-125a-5p were analyzed.
RESULTS: miRNA-125a-5p expression was upregulated in individuals with bvFTD compared with controls (fold change = 2.02). No significant differences between groups were observed for miRNA-30c-5p. An inverse correlation was identified between miRNA-125a-5p expression and age within the bvFTD group. Pathway enrichment analysis revealed that miRNA-125a-5p was significantly involved in the regulation of genes associated with insulin receptor signaling, SUMOylation, SUMO E3 ligase-mediated protein modification, SUMOylation of chromatin organization proteins, estrogen-dependent gene expression, extracellular exosome pathways, neuron migration, microtubule dynamics, and nervous system development.
CONCLUSIONS: These findings suggest that miRNA-125a-5p may play an important role in FTD-related biological pathways, underscoring its potential as a molecular marker in the pathophysiology of this disorder.
METHODS: Twenty patients with bvFTD and 20 cognitively healthy controls, matched for age and sex, were included in the study. Serum levels of miRNA-30c-5p and miRNA-125a-5p were analyzed.
RESULTS: miRNA-125a-5p expression was upregulated in individuals with bvFTD compared with controls (fold change = 2.02). No significant differences between groups were observed for miRNA-30c-5p. An inverse correlation was identified between miRNA-125a-5p expression and age within the bvFTD group. Pathway enrichment analysis revealed that miRNA-125a-5p was significantly involved in the regulation of genes associated with insulin receptor signaling, SUMOylation, SUMO E3 ligase-mediated protein modification, SUMOylation of chromatin organization proteins, estrogen-dependent gene expression, extracellular exosome pathways, neuron migration, microtubule dynamics, and nervous system development.
CONCLUSIONS: These findings suggest that miRNA-125a-5p may play an important role in FTD-related biological pathways, underscoring its potential as a molecular marker in the pathophysiology of this disorder.