Journal of biomedical optics · 2025
Noninvasive quantitative assessment of oral submucosal fibrosis in vivo using optical coherence elastography.
СтатьяНазвание и аннотация: Перевод в очереди
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Yang Yuhao, Ye Chaoqun, Tang Mengzhen, Li Zekun, Yang Xinyu, He Xingdao, Chen Weihua, Yang Jian
Аннотация
SIGNIFICANCE: Optical coherence elastography (OCE) is a noninvasive imaging technique with high sensitivity and resolution that can be used for mucocutaneous imaging. Oral submucous fibrosis (OSF) is a chronic disease that has a tendency to become cancerous. Nevertheless, there are a few noninvasive methods for early detection of OSF.
AIM: A piezoelectric transducer-based (PZT) OCE technique was devised to noninvasively assess the structural and mechanical properties of mucosa in healthy and fibrotic oral diseases.
APPROACH: We first validated the accuracy and reliability of the OCE system for tissue elasticity detection by means of a heterogeneous agar model. The structural and biomechanical characteristics of the regional tissues were then evaluated by examining the oral mucosa of both healthy and fibrotic SD rats.
RESULTS: Normal and fibrotic tissue stiffness differed significantly ( p < 0.05 ). The elastic wave velocity was 6.44 ± 0.30 m / s in the normal group and 14.2 ± 0.91 m / s in the fibrotic group. After converting the results to Young's modulus, the stiffness of the healthy buccal tissues and the fibrotic buccal tissues were 130.71 ± 12.01 and 636.15 ± 79.17 kPa , respectively ( p < 0.05 ).
CONCLUSIONS: OCE can differentiate between normal and fibrotic tissue based on elasticity and optical properties. Healthy buccal tissues were softer than diseased tissues.
AIM: A piezoelectric transducer-based (PZT) OCE technique was devised to noninvasively assess the structural and mechanical properties of mucosa in healthy and fibrotic oral diseases.
APPROACH: We first validated the accuracy and reliability of the OCE system for tissue elasticity detection by means of a heterogeneous agar model. The structural and biomechanical characteristics of the regional tissues were then evaluated by examining the oral mucosa of both healthy and fibrotic SD rats.
RESULTS: Normal and fibrotic tissue stiffness differed significantly ( p < 0.05 ). The elastic wave velocity was 6.44 ± 0.30 m / s in the normal group and 14.2 ± 0.91 m / s in the fibrotic group. After converting the results to Young's modulus, the stiffness of the healthy buccal tissues and the fibrotic buccal tissues were 130.71 ± 12.01 and 636.15 ± 79.17 kPa , respectively ( p < 0.05 ).
CONCLUSIONS: OCE can differentiate between normal and fibrotic tissue based on elasticity and optical properties. Healthy buccal tissues were softer than diseased tissues.