The Journal of clinical endocrinology and metabolism · 2026
Work Loss and Income Before and After Diagnosis of Addison's Disease: A Population-Based Longitudinal Study.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Stergianos Stavros, Everhov Åsa H, Söderling Jonas, Skov Jakob, Bensing Sophie
Аннотация
CONTEXT: The effect of autoimmune Addison's disease (AAD) on work ability and income over time remains unclear.
OBJECTIVE: This work aimed to evaluate differences and temporal trends in income and lost workdays among patients with AAD before and after diagnosis, vs matched general population comparators. This nationwide, register-based cohort study was conducted in Sweden. We linked the Swedish Addison Register with national health registers to identify 716 working-age individuals (aged 20-62 years) with incident AAD 2003 to 2019 and 3271 general-population comparators matched by sex, age, county, calendar year, and education level. Annual work loss, taxable earnings, and disposable income were examined over a 10-year period around diagnosis using linear (work loss) and quantile (earnings, income) regression.
RESULTS: Patients with AAD had significantly more work loss than comparators from 1 year before to 3 years after diagnosis, with the largest difference the year after diagnosis (mean difference: 30.5 days; 95% CI, 22.9-38.0 days). Median taxable earnings were lower in patients with AAD 1 year before (median difference: $-1107; 95% CI, $-2042 to $-173; P = .02) and 1 year after diagnosis ($-1105; 95% CI, $-2166 to $-43; P = .04). Disposable income was also reduced 1 year after diagnosis (median difference: $-1084; 95% CI, $-1813 to $-354; P = .004).
CONCLUSION: In AAD, increased work loss and reduced earnings and income were concentrated around diagnosis, peaking in the year after. Reassuringly, both absence from work and income normalized within 4 years following diagnosis.
OBJECTIVE: This work aimed to evaluate differences and temporal trends in income and lost workdays among patients with AAD before and after diagnosis, vs matched general population comparators. This nationwide, register-based cohort study was conducted in Sweden. We linked the Swedish Addison Register with national health registers to identify 716 working-age individuals (aged 20-62 years) with incident AAD 2003 to 2019 and 3271 general-population comparators matched by sex, age, county, calendar year, and education level. Annual work loss, taxable earnings, and disposable income were examined over a 10-year period around diagnosis using linear (work loss) and quantile (earnings, income) regression.
RESULTS: Patients with AAD had significantly more work loss than comparators from 1 year before to 3 years after diagnosis, with the largest difference the year after diagnosis (mean difference: 30.5 days; 95% CI, 22.9-38.0 days). Median taxable earnings were lower in patients with AAD 1 year before (median difference: $-1107; 95% CI, $-2042 to $-173; P = .02) and 1 year after diagnosis ($-1105; 95% CI, $-2166 to $-43; P = .04). Disposable income was also reduced 1 year after diagnosis (median difference: $-1084; 95% CI, $-1813 to $-354; P = .004).
CONCLUSION: In AAD, increased work loss and reduced earnings and income were concentrated around diagnosis, peaking in the year after. Reassuringly, both absence from work and income normalized within 4 years following diagnosis.