Frontiers in neurology · 2025
Visuospatial processing in patients with Alzheimer's disease and cerebral amyloid angiopathy.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Costa Ana Sofia, Albrecht Milena, Ridwan Hani, Schulz Jörg B, Reetz Kathrin, Pinho João
Аннотация
INTRODUCTION: There is a well-established but poorly understood pathological and clinical overlap between cerebral amyloid angiopathy (CAA) and Alzheimer's disease (AD). Some studies have suggested a posterior predominance of CAA-related lesions, but it remains unclear how well this can be captured by specific measures of low- to high-level visual cortical processing.
METHODS: We compared the characteristics of 30 patients with AD and/or CAA, grouped by impairment measures of low- to mid-level visual cortical processing, and explored associations with clinical characteristics, neurodegeneration biomarkers, CAA imaging features, and volumetric structural measures.
RESULTS: Twenty participants were classified as impaired on tasks of low- to mid-level visual cortical function. Impairment in these tasks was associated with performance on more complex visuoconstruction tasks, which in turn showed a correlation with structural integrity volume and cortical thickness in the occipital lobe. We found no association between impairment in low- to mid-level visual cortical functions or visuoconstruction tasks and specific measures of CAA or AD pathology.
DISCUSSION: Impairments in visuospatial functions, although reflecting structural damage in posterior brain regions, were not independently associated with markers of CAA or AD.
METHODS: We compared the characteristics of 30 patients with AD and/or CAA, grouped by impairment measures of low- to mid-level visual cortical processing, and explored associations with clinical characteristics, neurodegeneration biomarkers, CAA imaging features, and volumetric structural measures.
RESULTS: Twenty participants were classified as impaired on tasks of low- to mid-level visual cortical function. Impairment in these tasks was associated with performance on more complex visuoconstruction tasks, which in turn showed a correlation with structural integrity volume and cortical thickness in the occipital lobe. We found no association between impairment in low- to mid-level visual cortical functions or visuoconstruction tasks and specific measures of CAA or AD pathology.
DISCUSSION: Impairments in visuospatial functions, although reflecting structural damage in posterior brain regions, were not independently associated with markers of CAA or AD.