Thromboembolic and cerebrovascular events as initial clues to acromegaly: A clinical case series and review of pathophysiologic links.

Acromegaly is a rare endocrine disorder with an insidious onset and delayed diagnosis, and emerging evidence suggests a potential link to an increased risk of thromboembolic and cerebrovascular events. We present three cases where vascular events were the initial or incidental diagnostic clue. Case 1 involves a 52-year-old man with pulmonary embolism who was subsequently diagnosed with acromegaly. Case 2 describes a 30-year-old man with bilateral pulmonary embolism and a delayed diagnosis of acromegaly. Case 3 reports a 44-year-old man who presented with a transient ischemic attack, leading to the incidental discovery of a pituitary microadenoma and a diagnosis of acromegaly. All patients showed a clinical or biochemical response to therapy. These cases highlight the importance of considering acromegaly in patients with unexplained thromboembolic or cerebrovascular events, as early diagnosis and treatment are crucial for reducing long-term morbidity.