Digestive diseases and sciences · 2025
Prospective, Observational Study of the Efficacy, and Tolerability of a Same-Day, Low-Volume D-Sorbitol, Ascorbic Acid, and Sodium Picosulfate Regimen for Colonoscopy Bowel Preparation.
СтатьяНаблюдательное исследованиеМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
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Kim Jae Hyun, Ahn Sang Wook, Lee Seong Dae, Choi Sung Woo, Park Seun Ja
Аннотация
BACKGROUND AND AIMS: Low-volume, single-dose bowel preparations may improve patient convenience and compliance while maintaining cleansing quality. This study evaluated the efficacy and safety of a same-day, low-volume, single-dose D-sorbitol, ascorbic acid, and sodium picosulfate bowel cleansing regimen in routine outpatient practice.
METHODS: From May 2022 to July 2025, a prospective, multicenter post-marketing surveillance was conducted in four centers in Korea. Adult outpatients aged 19 to 80 years scheduled for elective colonoscopy and prescribed the study regimen were enrolled, excluding those with suspected bowel obstruction or severe comorbidities. The regimen consisted of 230 mL of reconstituted solution followed by 460 mL of water, administered 4-5 h before colonoscopy. Cleansing quality was graded using the Harefield Cleansing Scale (HCS); adequate cleansing was defined as Grade A or B. Secondary outcomes were regimen completion and adverse events. All variables were summarized using descriptive statistics.
RESULTS: A total of 608 patients (mean age 53.0 ± 12.9 years; 49.8% male; mean BMI 23.8 ± 3.2 kg/m2) were analyzed. Adequate cleansing was achieved in 96.4% (HCS Grade A: 68.1%, Grade B: 28.3%), with a regimen completion rate of 99.7%. Polyps were detected in 249 of 608 patients (41.0%), with a higher detection rate in men than in women (49.2% vs. 32.8%, p < 0.001). Adverse events occurred in 14.6% of patients, most commonly nausea (9.9%) and vomiting (5.1%). All adverse events were mild or moderate, resolved within 24 h, and required no hospitalization.
CONCLUSION: This prospective, observational study demonstrated that a same-day, low-volume D-sorbitol, ascorbic acid, and sodium picosulfate bowel cleansing regimen showed high efficacy, excellent completion rates, and a favorable safety profile in outpatient colonoscopy practice. This could represent a convenient alternative to traditional split-dose preparations, potentially improving patient compliance.
METHODS: From May 2022 to July 2025, a prospective, multicenter post-marketing surveillance was conducted in four centers in Korea. Adult outpatients aged 19 to 80 years scheduled for elective colonoscopy and prescribed the study regimen were enrolled, excluding those with suspected bowel obstruction or severe comorbidities. The regimen consisted of 230 mL of reconstituted solution followed by 460 mL of water, administered 4-5 h before colonoscopy. Cleansing quality was graded using the Harefield Cleansing Scale (HCS); adequate cleansing was defined as Grade A or B. Secondary outcomes were regimen completion and adverse events. All variables were summarized using descriptive statistics.
RESULTS: A total of 608 patients (mean age 53.0 ± 12.9 years; 49.8% male; mean BMI 23.8 ± 3.2 kg/m2) were analyzed. Adequate cleansing was achieved in 96.4% (HCS Grade A: 68.1%, Grade B: 28.3%), with a regimen completion rate of 99.7%. Polyps were detected in 249 of 608 patients (41.0%), with a higher detection rate in men than in women (49.2% vs. 32.8%, p < 0.001). Adverse events occurred in 14.6% of patients, most commonly nausea (9.9%) and vomiting (5.1%). All adverse events were mild or moderate, resolved within 24 h, and required no hospitalization.
CONCLUSION: This prospective, observational study demonstrated that a same-day, low-volume D-sorbitol, ascorbic acid, and sodium picosulfate bowel cleansing regimen showed high efficacy, excellent completion rates, and a favorable safety profile in outpatient colonoscopy practice. This could represent a convenient alternative to traditional split-dose preparations, potentially improving patient compliance.