Ciclosporin A in acrodermatitis continua.

A case is presented of a 58-year-old female exhibiting a severe pustular psoriasis of the acrodermatitis continua type treated with ciclosporin A. The disease which had lasted for 10 years and had lead to 14 hospitalizations had previously been treated with methotrexate, systemic steroids, etretinate, colchicine, hydroxyurea and PUVA, or combinations of some of these drugs without producing complete remissions. Ciclosporin A (14 mg/kg/day/reduced to 7.5 mg/kg/day) produced complete remission in three weeks. Whether the patient can be maintained on low-dose ciclosporin A without toxicity remains to be seen. The drug, however, seems to be effective in bringing the disease under control.