Tuberculosis (Edinburgh, Scotland) · 2022
Differences in biomarker concentrations in serum and urine of patients with Ocular Tuberculosis - A prospective descriptive study.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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van der Colff Fredrich J, Snyders Candice, Walzl Gerhard, Chegou Novel, Smit Derrick
Аннотация
PURPOSE: To describe biomarker concentrations in serum and urine of South African patients with ocular tuberculosis (OTB).
METHODS: A prospective study to compare 29 urine and serum biomarkers in 14 OTB patients at a tertiary eye clinic.
RESULTS: Median age of participants (7 male and 7 female) was 38.5 years (range 25-73) Most biomarker concentrations were significantly higher in serum than in urine (p < 0.01). Only 2 (IL-1RA and IL-2) showed higher concentrations in urine than serum (p < 0.01). Three biomarkers (sIL-2Ra, sTNFRI and IFNγ) showed no difference in concentration between urine and serum (p > 0.05).
CONCLUSIONS: Most biomarkers tested showed significant differences in concentration between serum and urine and therefore these 2 biofluids cannot be used interchangeably when studying biomarker profiles. One notable exception is IFNγ as its concentration did not differ between serum and urine.
METHODS: A prospective study to compare 29 urine and serum biomarkers in 14 OTB patients at a tertiary eye clinic.
RESULTS: Median age of participants (7 male and 7 female) was 38.5 years (range 25-73) Most biomarker concentrations were significantly higher in serum than in urine (p < 0.01). Only 2 (IL-1RA and IL-2) showed higher concentrations in urine than serum (p < 0.01). Three biomarkers (sIL-2Ra, sTNFRI and IFNγ) showed no difference in concentration between urine and serum (p > 0.05).
CONCLUSIONS: Most biomarkers tested showed significant differences in concentration between serum and urine and therefore these 2 biofluids cannot be used interchangeably when studying biomarker profiles. One notable exception is IFNγ as its concentration did not differ between serum and urine.