Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
Development and validation of novel cognitive tests in Mandarin-speaking older Americans.
СтатьяВалидационное исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Hu William T, Chen Michelle H, Li Mei-Ling, Su Guibin, Li Oceanna Y, Anthony Mia, Raphail Ann-Marie, Kota Karthik J, Nayyar Ashima, Kaluzova Milota, Chang Chun-Yuan, Horvath Hayley, Jomartin Mini, Migut Michelle, Chao Steven Z, Samudra Niyatee, Henderson Victor W, Lin F Vankee
Аннотация
INTRODUCTION: Mandarin Chinese has the largest number of native speakers globally, yet few Mandarin cognitive tests have undergone rigorous validation in multicultural settings for Alzheimer's disease (AD) detection.
METHODS: We adapted or developed Mandarin cognitive tests to assess memory, executive, and language functions (including new Chinese character, phoneme, and homophone fluency tasks) and then prospectively recruited 208 older adults at two US centers to determine the tests' reliability as well as convergent, construct, and concurrent validity.
RESULTS: All Mandarin cognitive measures had high test-retest reliability (intraclass correlation coefficients of 0.680to 0.849), and English letter-guided fluency best correlated with Chinese phoneme and homophone fluency. Factor analysis revealed six factors that underlie 16 cognitive measures, with at least one abnormal executive function or a story memory test associated with mild cognitive impairment and elevated plasma p-Tau217.
DISCUSSION: Validated cognitive measures provide culturally and linguistically appropriate tools to detect early AD among older Chinese Americans.
METHODS: We adapted or developed Mandarin cognitive tests to assess memory, executive, and language functions (including new Chinese character, phoneme, and homophone fluency tasks) and then prospectively recruited 208 older adults at two US centers to determine the tests' reliability as well as convergent, construct, and concurrent validity.
RESULTS: All Mandarin cognitive measures had high test-retest reliability (intraclass correlation coefficients of 0.680to 0.849), and English letter-guided fluency best correlated with Chinese phoneme and homophone fluency. Factor analysis revealed six factors that underlie 16 cognitive measures, with at least one abnormal executive function or a story memory test associated with mild cognitive impairment and elevated plasma p-Tau217.
DISCUSSION: Validated cognitive measures provide culturally and linguistically appropriate tools to detect early AD among older Chinese Americans.