JACC. Case reports · 2025
Turning the Tide: Unraveling Aortic Dynamics and Patent Foramen Ovale in Platypnea-Orthodeoxia Syndrome.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Ahmed Dalia, Abbas Shuja, Bhatia Raghav T, Williams Oyeronke, Antony Renjith
Аннотация
BACKGROUND: Platypnea-orthodeoxia syndrome (POS) is a rare disorder characterized by positional dyspnea and hypoxemia due to right-to-left shunting, often through a patent foramen ovale (PFO). It requires both an anatomical substrate and a functional trigger.
CASE SUMMARY: A man in his 70s presented with acute cerebellar stroke, breathlessness, and profound hypoxia worsened by the upright position. He tested positive for COVID-19, and computed tomography demonstrated a small pulmonary embolism, aorta dilation, and steep aortic angulation. Transthoracic echocardiography with a bubble study confirmed the presence of a PFO with right-to-left shunting during the Valsalva maneuver. Percutaneous PFO closure resulted in clinical improvement and resolution of hypoxemia.
DISCUSSION: This case highlights the interplay of PFO, aortic dilatation, and aortic angulation as key contributors to POS. Multimodal imaging is crucial for diagnosis and management.
TAKE-HOME MESSAGE: POS should be considered in positional hypoxia cases, and imaging is essential for diagnosis and treatment planning.
CASE SUMMARY: A man in his 70s presented with acute cerebellar stroke, breathlessness, and profound hypoxia worsened by the upright position. He tested positive for COVID-19, and computed tomography demonstrated a small pulmonary embolism, aorta dilation, and steep aortic angulation. Transthoracic echocardiography with a bubble study confirmed the presence of a PFO with right-to-left shunting during the Valsalva maneuver. Percutaneous PFO closure resulted in clinical improvement and resolution of hypoxemia.
DISCUSSION: This case highlights the interplay of PFO, aortic dilatation, and aortic angulation as key contributors to POS. Multimodal imaging is crucial for diagnosis and management.
TAKE-HOME MESSAGE: POS should be considered in positional hypoxia cases, and imaging is essential for diagnosis and treatment planning.