Journal of surgical oncology · 2024
Circulating tumor DNA in management of primary liver malignancy: A review of the literature and future directions.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
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Tocci Noah X, Wehrle Chase J, Sun Keyue, Jiao Chunbao, Hong Hanna, Gross Abby, Allkushi Erlind, Uysal Melis, Linganna Maureen Whitsett, Stackhouse Katheryn, Hashimoto Koji, Schlegel Andrea, Walsh R Matthew, Miller Charles, Kwon David C H, Aucejo Federico
Аннотация
Primary liver malignancies are a serious and challenging global health concern. The most common primary tumors are hepatocellular carcinoma and cholangiocarcinoma. These diseases portend poor prognosis when presenting with progressive, extensive disease. There is a critical need for improved diagnosis, therapeutic intervention, and monitoring surveillance in liver-related malignancies. Liquid biopsy using ctDNA provides an opportunity for growth within these domains for liver-related malignancy. However, ctDNA is relatively understudied in this field compared with other solid tumor types, possibly due to the complex nature of the pathology. In this review, we aim to discuss ctDNA, the current literature, and future directions of this technology within primary liver malignancies.