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bioRxiv : the preprint server for biology · 2026

Brain Age in Conduct Disorder:: A Mega-Analysis of the ENIGMA Antisocial Behavior Working Group.

СтатьяПрепринтНазвание и аннотация: Перевод в очереди
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Dugré Jules R, Gao Yidian, Staginnus Marlene, Marsh Abigail A, Kypta-Vivanco Alexandra, Cubillo Ana I, Dietrich Andrea, Bernhard Anka, Martinelli Anne, Dykstra Anouk H, Smaragdi Areti, Sethi Arjun, Bokde Arun L W, Franke Barbara, Arango Celso, Boateng Charlotte P S, Stadler Christina, Freitag Christine M, Townsend Christopher D, Monk Christopher S, Hagan Cindy C, Mitchell Colter, Dong Daifeng, Díaz Dana E, Brandeis Daniel, Murphy Declan, Sukhodolsky Denis G, Sonuga-Barke Edmund J S, Cardinale Elise M, Viding Essi, Kohls Gregor, Schumann Gunter, Cornwell Harriet, Phillips Harriet, Westerman Heidi B, Chen Hui, Sagar-Ouriaghli Ilyas, Rogers Jack C, Buitelaar Jan K, Martinot Jean-Luc, Glennon Jeffrey C, Zhou Jiansong, Zhang Jibiao, Naaijen Jilly, Castro-Fornieles Josefina, Michalska Kalina J, Gonzalez-Madruga Karen, Ibrahim Karim, Sully Kate, Berluti Kathryn, Konrad Kerstin, Lamers Kim, Mycue Leah E, Passamonti Luca, Hyde Luke W, Oosterling Maaike, Alonso Maria Jose Penzol, Stevens Michael C, Craig Michael, Rosa-Justicia Mireia, Ploe Montana L, Holz Nathalie, van der Wee Nic J A, Toschi Nicola, Jabeen Nimrah, Raschle Nora M, Colins Olivier F, Santosh Paramala, Aggensteiner Pascal-M, Hoekstra Pieter J, Ming Qingsen, Wu Qiong, Jackson Rebecca L, Ma Ren, Blair Robert J R, Vermeiren Robert, Pauli Ruth, Roberts Ruth, Burt S Alexandra, Bajaj Sahil, Chester Sally C, Minosse Silvia, Desrivieres Sylvane, Banaschewski Tobias, Schulze Ulrike M E, Chen Xianliang, Wang Xiaoping, Sun Xiaoqiang, Jiang Yali, Jahanshad Neda, Thomopoulos Sophia I, Ching Christopher R K, Kang Melody J Y, Thompson Paul M, Pine Daniel S, Baskin-Sommers Arielle, Cecil Charlotte A M, Aghajani Moji, Fairchild Graeme, ENIGMA Antisocial Behavior Consortium, De Brito Stephane A

Аннотация

Conduct disorder (CD) is the leading global cause of mental health burden in children and adolescents and has recently been hypothesized to be a neurodevelopmental disorder. Although prior research has identified neuroanatomical differences associated with CD, it remains unclear whether these differences reflect atypical brain development. Here, we investigated the difference between an individual's brain age and chronological age as a proxy for variations in brain maturation. Using a pretrained model, we estimated brain age from structural neuroimaging data obtained from 1,119 youth with CD and 1,183 typically developing controls across 14 international cohorts participating in the ENIGMA-Antisocial Behavior Working Group. Youth with CD exhibited a statistically robust but small acceleration in brain age compared to typically developing youth (around 0.50 years), which was restricted to the adolescence-onset subtype of the disorder. Our large-scale, coordinated analysis provides the first evidence of accelerated neurodevelopment as a potential mechanism underlying CD.

ИП Урсолов Владлен Сергеевич

ИНН 500118482352 · ОГРНИП 314500117700049

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