Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
Vulnerability of the locus coeruleus-entorhinal cortex white matter tract in autosomal dominant Alzheimer's disease.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Koops Elouise A, Giudicessi Averi, Baena Ana, Martinez Lusiana, Bonillas-Felix Nikole, Medrano Randy, Dutta Joyita, Gonzalez Isabela, Alvarez Sergio, Aguillon David, Quiroz Yakeel T, Jacobs Heidi I L
Аннотация
INTRODUCTION: Locus coeruleus (LC) structural integrity declines early in sporadic and autosomal dominant Alzheimer's disease (AD). We examined LC-entorhinal cortex (LC-EC) tract integrity and its association with amyloid and tau pathology and memory in autosomal dominant AD (ADAD).
METHODS: We examined associations between diffusion-weighted imaging-derived LC-EC tract characteristics and age, sex, amyloid (Pittsburgh Compound B [PiB]), entorhinal tau ([18F]-flortaucipir [18F-FTP] positron emission tomography [PET]), and memory in PSEN1-E280A mutation carriers (n = 30) and non-carriers (n = 33).
RESULTS: LC-EC tract integrity was lower in females and older individuals in both non-carriers and carriers. In mutation carriers, lower tract integrity was associated with higher entorhinal tau and poorer memory, with tau and amyloid mediating the tract-memory relationship in the entire sample but not in unimpaired carriers.
DISCUSSION: These findings highlight the LC-EC tract as an early disease vulnerability marker in ADAD, with tract disruption associated with memory decline across disease stages, a relationship further mediated by entorhinal tau pathology as disease progresses.
METHODS: We examined associations between diffusion-weighted imaging-derived LC-EC tract characteristics and age, sex, amyloid (Pittsburgh Compound B [PiB]), entorhinal tau ([18F]-flortaucipir [18F-FTP] positron emission tomography [PET]), and memory in PSEN1-E280A mutation carriers (n = 30) and non-carriers (n = 33).
RESULTS: LC-EC tract integrity was lower in females and older individuals in both non-carriers and carriers. In mutation carriers, lower tract integrity was associated with higher entorhinal tau and poorer memory, with tau and amyloid mediating the tract-memory relationship in the entire sample but not in unimpaired carriers.
DISCUSSION: These findings highlight the LC-EC tract as an early disease vulnerability marker in ADAD, with tract disruption associated with memory decline across disease stages, a relationship further mediated by entorhinal tau pathology as disease progresses.