Internal medicine (Tokyo, Japan) · 2022
Subcutaneous Panniculitis-like T-cell Lymphoma with a HAVCR2 Mutation Diagnosed after 10 Years of Treatment with Glucocorticoids and Cyclosporine as Lupus Panniculitis.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Yamamoto Yoshiki, Mitsui Asako, Noda Kentaro, Suzuki Yasuo, Sawaki Akihiko, Shinoki Toshihiko, Imai Hiroshi, Miyazaki Kana, Tawara Isao, Nakajima Ayako
Аннотация
Subcutaneous panniculitis-like T cell lymphoma (SPTCL) is a very rare cutaneous T cell lymphoma that has been reported to be associated with autoimmune disorders but is most commonly associated with systemic lupus erythematosus. We herein report a 26-year-old man thought to have lupus panniculitis (LP) treated for 10 years with corticosteroids and cyclosporine. After several relapses with panniculitis, he was finally diagnosed with SPTCL, which was confirmed to have a HAVCR2 mutation for p.Tyr82Cys. We emphasize that rheumatologists should be aware of the possibility of SPTCL, despite its rare appearance, when making a diagnosis of LP or when encountering clinical manifestations that are not consistent with LP.