Distinct Substrates of Idiopathic Ventricular Fibrillation Revealed by Arrhythmia Characteristics on Implantable Cardioverter-Defibrillator.
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Haïssaguerre Michel, Sellal Jean-Marc, Benali Karim, de Becker Benjamin, Defaye Pascal, Pascale Patrizio, Martins Raphael, Mabo Philippe, Xhaet Olivier, Extramiana Fabrice, Surget Elodie, Lavergne Thomas, Marijon Eloi, Adragao Pedro, Carvalho Maria Salomé, Milliez Paul-Ursmar, Laredo Mickael, Gandjbakhch Estelle, Giustetto Carla, Gaita Fiorenzo, Tilz Roland, Jesel-Morel Laurence, Steinfurt Johannes, Arentz Thomas, Knecht Sebastien, Duytschaever Mattias, Roten Laurent, Reichlin Tobias, Fatemi Marjaneh, Mansourati Jacques, Kouakam Claude, Bessière Francis, Chevalier Philippe, Tadros Rafik, Macle Laurent, Gallego Francisco, Hadjis Alexios, Sacher Frederic, Pereira Dylan, Hourdain Jerome, Deharo Jean-Claude, Eschalier Romain, Massoulié Grégoire, Maury Philippe, Latcu Decebal Gabriel, Anselme Frederic, Duchateau Josselin, Tixier Romain, Nademanee Koonlawee, Nogami Akihiko, de Groot Natasja, Vigmond Edward, Bernus Olivier, Strik Marc, Bordachar Pierre, Cathala Aude, Bouteiller Xavier, Dubois Remi, Ploux Sylvain
Аннотация
OBJECTIVES: This study sought to evaluate the characteristics of recurrent VF recorded on implantable defibrillator electrograms, associated with these substrates.
METHODS: This was a multicenter collaboration study. At 32 centers, we selected patients with an initial diagnosis of IVF and recurrent arrhythmia at follow-up without antiarrhythmic drugs, in whom mapping demonstrated Purk or MiCM substrate. We analyzed variables related to previous ectopy, sinus rate preceding VF, trigger, and initial VF cycle lengths. Logistic regression with cross validation was used to evaluate the performance of criteria to discriminate Purk or MiCM substrates.
RESULTS: Among 95 patients (35 women, age 35 ± 11 years) meeting the inclusion criteria, IVF was associated with MiCM in 41 and Purk in 54 patients. A total of 117 arrhythmia recurrences including 91% VF were recorded on defibrillator. Three variables were mostly discriminant. Sinus tachycardia (≤570 ms) was more frequent in MiCM (35.9% vs 13.4%, P = 0.014) whereas short-coupled (<350 ms) triggers were most frequent in Purk-related VF (95.5% vs 23.1%, P = 0.001), which also had shorter VFCLs (182 ± 15 ms vs 215 ± 24 ms, P < 0.001).The multivariable combination provided the highest prediction (accuracy = 0.93 ± 0.05, range 0.833-1.000), discriminating 81% of IVF substrates with a high probability (>80%). Ectopy were inconsistently present before VF.
CONCLUSIONS: Characteristics of arrhythmia recurrences on implantable cardioverter- defibrillator provide phenotypic markers of the distinct and hidden substrates underlying IVF. These findings have significant clinical and genetic implications.