Journal of the American Academy of Dermatology · 2025
Patterns and pitfalls: Dermoscopic differentiation of early-stage mycosis fungoides, atopic dermatitis, and psoriasis.
СтатьяСравнительное исследованиеНазвание и аннотация: Перевод в очереди
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Balan Kerem, Lallas Aimilios, Akdogan Neslihan
Аннотация
BACKGROUND: Mycosis fungoides (MF), psoriasis (Pso), and atopic dermatitis (AD) may present with overlapping clinical features, which may lead to delayed diagnosis. Dermoscopy, including ultraviolet (UV) mode, can help distinguish disease-specific patterns.
OBJECTIVE: To compare dermoscopic and UV features of early-stage MF, Pso, and AD.
METHODS: In this prospective cohort study, 159 patients (MF: 55, Pso: 53, AD: 51) were examined with dermoscopy and UV mode. Vascular patterns, scale features, background color, structureless areas, and vessel density per mm2 were analyzed. Group differences were assessed with chi-square/Fisher's exact tests or ANOVA/Welch ANOVA, using Bonferroni/Games-Howell corrections.
RESULTS: MF showed linear and spermatozoa-like vessels, scaling along skin furrows, focal structureless areas, and the lowest vessel density. Pso was defined by uniformly distributed dotted vessels on a bright-red background with diffuse scaling and the highest vessel density. AD showed mainly dotted vessels with additional linear vessels, along with yellow-orange scale, ulceration, dystrophic hairs, and intermediate vessel density. UV imaging improved visualization of structureless areas and scaling edges.
LIMITATIONS: Single-center design, modest sample size, and restriction to early stages may limit generalizability.
CONCLUSION: Dermoscopy with UV mode shows distinct features in MF, Pso, and AD. This approach may support early, noninvasive differentiation.
OBJECTIVE: To compare dermoscopic and UV features of early-stage MF, Pso, and AD.
METHODS: In this prospective cohort study, 159 patients (MF: 55, Pso: 53, AD: 51) were examined with dermoscopy and UV mode. Vascular patterns, scale features, background color, structureless areas, and vessel density per mm2 were analyzed. Group differences were assessed with chi-square/Fisher's exact tests or ANOVA/Welch ANOVA, using Bonferroni/Games-Howell corrections.
RESULTS: MF showed linear and spermatozoa-like vessels, scaling along skin furrows, focal structureless areas, and the lowest vessel density. Pso was defined by uniformly distributed dotted vessels on a bright-red background with diffuse scaling and the highest vessel density. AD showed mainly dotted vessels with additional linear vessels, along with yellow-orange scale, ulceration, dystrophic hairs, and intermediate vessel density. UV imaging improved visualization of structureless areas and scaling edges.
LIMITATIONS: Single-center design, modest sample size, and restriction to early stages may limit generalizability.
CONCLUSION: Dermoscopy with UV mode shows distinct features in MF, Pso, and AD. This approach may support early, noninvasive differentiation.