Oral surgery, oral medicine, oral pathology and oral radiology · 2025
Brown tumor of hyperparathyroidism in the maxillofacial region: a retrospective study with 19 patients.
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Chiliti Beatriz Afonso, Martin Regina Matsunaga, Santos-Silva Alan Roger, Matuck Bruno Fernandes, Machado Gustavo Grothe, Rocha André Caroli
Аннотация
OBJECTIVE: This study aimed to define the epidemiology and treatment approaches for hyperparathyroidism (HPT) and brown tumors, and to determine the time required for bone regeneration at the tumor site following parathyroid surgery.
STUDY DESIGN: We conducted a 24-year retrospective study involving patients diagnosed with brown tumors secondary to HPT at the University of São Paulo, Brazil. Data were collected from medical records, including information on disease diagnosis, HPT treatment, brown tumor management, laboratory test results, and imaging studies.
RESULTS: A total of 19 patients were included in the study, with a higher prevalence among women in their 30s and 40s. Most cases were associated with primary HPT, and surgery was the most common treatment for the parathyroid glands. Brown tumors were more frequently found in the maxilla, and osteoplasty was the most performed surgical intervention for these lesions. On average, bone regeneration at the tumor site occurred within 7 months.
CONCLUSIONS: A multidisciplinary approach is essential. The management of the HPT must take precedence over tumor treatment, which results in bone regeneration within the brown tumor. Allowing less invasive treatments with reduced risk of sequelae.
STUDY DESIGN: We conducted a 24-year retrospective study involving patients diagnosed with brown tumors secondary to HPT at the University of São Paulo, Brazil. Data were collected from medical records, including information on disease diagnosis, HPT treatment, brown tumor management, laboratory test results, and imaging studies.
RESULTS: A total of 19 patients were included in the study, with a higher prevalence among women in their 30s and 40s. Most cases were associated with primary HPT, and surgery was the most common treatment for the parathyroid glands. Brown tumors were more frequently found in the maxilla, and osteoplasty was the most performed surgical intervention for these lesions. On average, bone regeneration at the tumor site occurred within 7 months.
CONCLUSIONS: A multidisciplinary approach is essential. The management of the HPT must take precedence over tumor treatment, which results in bone regeneration within the brown tumor. Allowing less invasive treatments with reduced risk of sequelae.