Epigenomics · 2012
Epigenetic changes in lymphocytes of solvent-exposed individuals.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Godderis Lode, De Raedt Karel, Tabish Ali M, Poels Katrien, Maertens Nathalie, De Ruyck Kim, Bulterys Simon, Thierens Hubert, Viaene Maria K
Аннотация
AIM: We investigated global DNA methylation alterations in lymphocytes of solvent workers and chronic toxic encephalopathy (CTE) patients and explored potential gene-environment interactions for GST. POPULATION & METHODS: A cross-sectional study was set up in 41 referents, 128 solvent workers and 23 CTE patients.
RESULTS: We found a global DNA hypermethylation in the solvent-exposed population compared with the referents (p = 0.001, r = -0.544). Global DNA methylation was negatively associated with exposure. Furthermore, GSTP1 genotypic polymorphism was found to be significantly associated (p = 0.033) with global DNA hypomethylation, which indicates a potential role for gene-environment interaction in the etiology of solvent-induced neurobehavioral disorders.
CONCLUSION: This study indicates that solvent-induced DNA methylation alterations have an impact on neurotoxicity and development of CTE.
RESULTS: We found a global DNA hypermethylation in the solvent-exposed population compared with the referents (p = 0.001, r = -0.544). Global DNA methylation was negatively associated with exposure. Furthermore, GSTP1 genotypic polymorphism was found to be significantly associated (p = 0.033) with global DNA hypomethylation, which indicates a potential role for gene-environment interaction in the etiology of solvent-induced neurobehavioral disorders.
CONCLUSION: This study indicates that solvent-induced DNA methylation alterations have an impact on neurotoxicity and development of CTE.
Предметные рубрики MeSH
AdultCase-Control StudiesChronic DiseaseCross-Sectional StudiesDNA MethylationDNA Mutational AnalysisEpigenesis, GeneticFemaleGenome-Wide Association StudyGlutathione S-Transferase piHumansLymphocytesMaleMiddle AgedNeurotoxicity SyndromesOccupational ExposurePolymorphism, GeneticSolventsSurveys and Questionnaires