Archives de pediatrie : organe officiel de la Societe francaise de pediatrie · 2007
[Congenital transient leukemia: a case report].
Клинический случайАннотация на английскомСтатьяНазвание и аннотация: Перевод в очереди
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Li-Thiao-Te V, Bourges-Petit E, Capiod J C, Horle B, Micheli J, Morin G, Maingourd Y, Pautard B
Аннотация
UNLABELLED: Neonates with Down's syndrome have an increased risk for congenital leukaemia, particularly acute megakaryoblastic leukaemia (FAB, M7) which most often resolves spontaneously and is called transient leukaemia. It can be observed in non-constitutional trisomy 21 infants then presenting trisomy 21 on blasts cells.
OBSERVATION: We report a transient leukaemia with an isolated pericardial effusion in a phenotypically normal neonate. Trisomy 21 was found on blasts cells. Complete remission remains after 32 months.
DISCUSSION: Congenital leukaemias, with trisomy 21 on blasts cells have a good prognosis that justifies observation before using chemotherapy.
OBSERVATION: We report a transient leukaemia with an isolated pericardial effusion in a phenotypically normal neonate. Trisomy 21 was found on blasts cells. Complete remission remains after 32 months.
DISCUSSION: Congenital leukaemias, with trisomy 21 on blasts cells have a good prognosis that justifies observation before using chemotherapy.