Environmental toxicology and pharmacology · 2025
Exposure to airborne polychlorinated biphenyls and risk of uterine leiomyomata, endometriosis, and polycystic ovarian syndrome: A register-based Danish cohort study.
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Tøttenborg Sandra Søgaard, Wise Lauren Anne, Wesselink Amelia Kent, Nielsen Henriette Svarre, Petersen Kajsa Ugelvig, Fox Matthew P, Frederiksen Marie, Flachs Esben Meulengracht, Meyer Harald William, Hougaard Karin Sørig, Bonde Jens Peter, Deen Laura
Аннотация
OBJECTIVE: To assess whether exposure to lower-chlorinated PCBs from building materials is associated with increased incidence of UL, endometriosis, and PCOS in female residents.
METHODS: We studied 21,619 residents of two Danish partially PCB-contaminated housing areas from 1970 to 2018. Combining register-based relocation history with indoor air measurements, we quantified annual cumulative exposure (PCByear). Nationwide registers identified outcome diagnoses; Cox regression with time-varying exposure estimated hazard ratios (HR).
RESULTS: During ≈ 380,000 person-years, we identified 662 incident UL, 199 endometriosis, and 190 PCOS cases. Median exposure was 56.3 PCByear (5-95 percentile: 0.3-4952). Adjusted HRs per 4 ×interquartile range increase in PCByear (880 ng/m3×year) showed no association with UL (HR 0.99, 95 % CI 0.96-1.02), endometriosis (0.96, 95 % CI 0.90-1.02), or PCOS (HR 0.98, 95 % CI 0.93-1.03).
DISCUSSION: This first study of gynecological risks from residential PCB exposure found no effect, though exposure misclassification and outcome underascertainment may have biased results towards the null.
METHODS: We studied 21,619 residents of two Danish partially PCB-contaminated housing areas from 1970 to 2018. Combining register-based relocation history with indoor air measurements, we quantified annual cumulative exposure (PCByear). Nationwide registers identified outcome diagnoses; Cox regression with time-varying exposure estimated hazard ratios (HR).
RESULTS: During ≈ 380,000 person-years, we identified 662 incident UL, 199 endometriosis, and 190 PCOS cases. Median exposure was 56.3 PCByear (5-95 percentile: 0.3-4952). Adjusted HRs per 4 ×interquartile range increase in PCByear (880 ng/m3×year) showed no association with UL (HR 0.99, 95 % CI 0.96-1.02), endometriosis (0.96, 95 % CI 0.90-1.02), or PCOS (HR 0.98, 95 % CI 0.93-1.03).
DISCUSSION: This first study of gynecological risks from residential PCB exposure found no effect, though exposure misclassification and outcome underascertainment may have biased results towards the null.