HLA · 2024
HLA alleles associated to susceptibility to gliptin-associated bullous pemphigoid in Italian patients.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Andreani Marco, Mariotti Feliciana, Pira Anna, Locatelli Franco, Testa Giuseppe, Battarra Mariarosa, Caputi Priscilla, Scarabello Alessandra, Bellei Barbara, Di Campli Cristiana, Collina Maria Chiara, Esposito Ilaria, Giampetruzzi Anna Rita, Didona Biagio, Pitocco Dario, De Simone Clara, Di Zenzo Giovanni
Аннотация
Bullous pemphigoid (BP), although a rare disease, is the most frequent subepidermal autoimmune disorder. Treatment with gliptins, used for type 2 diabetes, was reported as associated with BP onset. To identify HLA alleles that may reflect a higher susceptibility to BP in the Italian population, we analysed 30 patients affected by idiopathic bullous pemphigoid (IBP) and 86 gliptin-associated BP (GABP) patients. A significant association between HLA-DQB1*03:01 allele and IBP and GABP patients was found. Of note, both IBP and GABP were significantly associated with one of the following haplotypes: DRB1*11:01, DRB3*02:02, DQA1*05:05, DQB1*03:01 or DRB1*11:04, DRB3*02:02, DQA1*05:05 and DQB1*03:01. These data identify, for the first time, potential markers of susceptibility to BP in the Italian population, especially when associated with gliptin intake.