medRxiv : the preprint server for health sciences · 2025
The REgistry of Flow and Perfusion Imaging for Artificial INtelligEnce with PET (REFINE PET): Rationale and Design.
СтатьяПрепринтНазвание и аннотация: Перевод в очереди
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Ramirez Giselle, Lemley Mark, Shanbhag Aakash, Kwiecinski Jacek, Miller Robert J H, Kavanagh Paul B, Liang Joanna X, Dey Damini, Slipczuk Leandro, Travin Mark I, Alexanderson Erick, Carvajal-Juarez Isabel, Packard René R S, Al-Mallah Mouaz, Einstein Andrew J, Feher Attila, Acampa Wanda, Knight Stacey, Le Viet T, Mason Steve, Sanghani Rupa, Wopperer Samuel, Chareonthaitawee Panithaya, Buechel Ronny R, Rosamond Thomas L, deKemp Robert A, Berman Daniel S, Di Carli Marcelo F, Slomka Piotr J
Аннотация
RATIONALE: The REgistry of Flow and Perfusion Imaging for Artificial INtelligEnce with PET (REFINE PET) was established to aggregate PET and associated computed tomography (CT) images with clinical data from hospitals around the world into one comprehensive research resource.
METHODS: REFINE PET is a multicenter, international registry that contains both clinical and imaging data. The PET scans were processed using QPET software (Cedars-Sinai Medical Center, Los Angeles, CA), while the CT scans were processed using deep learning (DL) to detect coronary artery calcium (CAC). Patients were followed up for the occurrence of major adverse cardiovascular events (MACE), which include death, myocardial infarction, unstable angina, and late revascularization (>90 days from PET).
RESULTS: The REFINE PET registry currently contains data for 35,588 patients from 14 sites, with additional patient data and sites anticipated. Comprehensive clinical data (including demographics, medical history, and stress test results) were integrated with more than 2200 imaging variables across 42 categories. The registry is poised to address a broad range of clinical questions, supported by correlating invasive angiography (within 6 months of MPI) in 5972 patients and a total of 9252 major adverse cardiovascular events during a median follow-up of 4.2 years.
CONCLUSION: The REFINE PET registry leverages the integration of clinical, multimodality imaging, and novel quantitative and AI tools to advance the role of PET/CT MPI in diagnosis and risk stratification.
METHODS: REFINE PET is a multicenter, international registry that contains both clinical and imaging data. The PET scans were processed using QPET software (Cedars-Sinai Medical Center, Los Angeles, CA), while the CT scans were processed using deep learning (DL) to detect coronary artery calcium (CAC). Patients were followed up for the occurrence of major adverse cardiovascular events (MACE), which include death, myocardial infarction, unstable angina, and late revascularization (>90 days from PET).
RESULTS: The REFINE PET registry currently contains data for 35,588 patients from 14 sites, with additional patient data and sites anticipated. Comprehensive clinical data (including demographics, medical history, and stress test results) were integrated with more than 2200 imaging variables across 42 categories. The registry is poised to address a broad range of clinical questions, supported by correlating invasive angiography (within 6 months of MPI) in 5972 patients and a total of 9252 major adverse cardiovascular events during a median follow-up of 4.2 years.
CONCLUSION: The REFINE PET registry leverages the integration of clinical, multimodality imaging, and novel quantitative and AI tools to advance the role of PET/CT MPI in diagnosis and risk stratification.