Journal of the American Academy of Dermatology · 2025
Racial differences in mycosis fungoides and Sézary syndrome: A multicenter cohort study.
СтатьяМногоцентровое исследованиеСравнительное исследованиеПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Allen Pamela B, Goyal Subir, Iyer Swaminathan, Talluru Sai, Huen Auris, Greenwell Brian, Scribner Jane, Paulino Darina, Speegle Shel, Baird Katelin, Beaven Anne, Switchenko Jeffrey M, Rangarajan Sunil, Mehta Amitkumar, O'Leary Colin, Case Katherine, Adams Brittany, Ayers Amy, Bhatti Safiyyah, Krishnasamy Shalini, Porcu Pierluigi, Sethi Tarsheen, Foss Francine, Lechowicz Mary Jo, Rozati Sima
Аннотация
BACKGROUND: The association between race on outcomes in mycosis fungoides and Sézary syndrome (MF/SS) is poorly understood.
OBJECTIVE: To evaluate the association between clinical characteristics, including self-identified race, on patient outcomes in a multicenter cohort study of patients with MF/SS.
METHODS: A retrospective cohort analysis was conducted at 7 academic institutions with high representation of Black patients with MF/SS. Patients diagnosed between 2010 and 2021 with consistent follow-up, confirmed diagnosis of MF/SS, and pathology reports available were eligible. Self-reported racial groups were obtained from medical records. Univariate and multivariable models and Kaplan-Meier assessments were analyzed for overall survival. The primary outcome was to assess differences in overall survival among Black patients. The hypotheses were formulated prior to data collection.
RESULTS: 883 patients with MF/SS were identified, including 419 (47.4%) Black and 464 (56.6%) White patients. Compared to White MF/SS patients, Black patients presented younger with higher stage at diagnosis and worse survival in the cohort aged more than 60 years.
LIMITATIONS: Referral bias due to the setting at tertiary care academic centers and lack of central pathologic review limits interpretation of this study.
CONCLUSIONS: Compared with White patients, Black patients with MF/SS have higher-risk clinical features and decreased survival in the older patients.
OBJECTIVE: To evaluate the association between clinical characteristics, including self-identified race, on patient outcomes in a multicenter cohort study of patients with MF/SS.
METHODS: A retrospective cohort analysis was conducted at 7 academic institutions with high representation of Black patients with MF/SS. Patients diagnosed between 2010 and 2021 with consistent follow-up, confirmed diagnosis of MF/SS, and pathology reports available were eligible. Self-reported racial groups were obtained from medical records. Univariate and multivariable models and Kaplan-Meier assessments were analyzed for overall survival. The primary outcome was to assess differences in overall survival among Black patients. The hypotheses were formulated prior to data collection.
RESULTS: 883 patients with MF/SS were identified, including 419 (47.4%) Black and 464 (56.6%) White patients. Compared to White MF/SS patients, Black patients presented younger with higher stage at diagnosis and worse survival in the cohort aged more than 60 years.
LIMITATIONS: Referral bias due to the setting at tertiary care academic centers and lack of central pathologic review limits interpretation of this study.
CONCLUSIONS: Compared with White patients, Black patients with MF/SS have higher-risk clinical features and decreased survival in the older patients.