Autochthonous chikungunya virus outbreak in Verona province, Italy, 2025.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Castilletti Concetta, Ancillotti Leonardo, Mori Antonio, Accordini Silvia, Deiana Michela, Cheri Samuele, Gianesini Natasha, Chesini Lorena Maria, Malagò Simone, Matucci Andrea, Cubi Federico, Zanchi Chiara, Cattaneo Paolo, Huits Ralph, Barzon Luisa, Pacenti Monia, Gentili Davide, Tonon Michele, Postiglione Chiara, Marchiori Francesco, Falcone Salvatore, Zerman Tamara, Gobbo Federica, Merakou Christina, Del Manso Martina, Montarsi Fabrizio, Venturi Giulietta, Pezzotti Patrizio, Buonfrate Dora, Varischi Giovanna, Palamara Anna Teresa, Russo Francesca, Gobbi Federico Giovanni
Аннотация
METHODS: In 2025, a dedicated surveillance protocol was implemented to assess local transmission of arboviral infections in Verona province, enabling early detection of a local CHIKV circulation. Following notification of the index case, investigations were conducted in accordance with the national and regional arbovirus surveillance plans, including comprehensive epidemiological, virological, and entomological analyses.
RESULTS: The index case was identified on 6 August 2025, with retrospective detection of the first case with symptom onset on 31 July; the primary case was not identified. As of 15 October, 69 cases were reported (62 confirmed, 7 probable), with a mean age of 55 years; 91.3% had identifiable epidemiological links, mainly clustered in two municipalities of the Verona province. Most cases (76.8%) occurred between mid-August and mid-September. The outbreak lasted approximately fifteen weeks, from the end of July to the mid of October. CHIKV-RNA was detectable in whole blood and, less frequently, urine only within the first five days after symptom onset, with higher viral loads in blood. CHIKV-specific IgM antibodies were detectable from days 4-5 and IgG from days 7-10. A total of 225 Aedes albopictus specimens were collected, all testing negative for CHIKV. Phylogenetic analysis revealed a highly homogeneous, monophyletic cluster within the East-Central-South African (ECSA) genotype, closely related to strains from the 2024-2025 Réunion outbreak.
CONCLUSIONS: This outbreak underscores the value of dedicated surveillance protocols for early detection of febrile/suspected arboviral cases, while also highlighting key vulnerabilities, namely, an undetected primary case and negative entomological findings, pointing to the need for lower testing thresholds and earlier, risk-based vector sampling.