JACC. Basic to translational science · 2024
Proteomic Profile of the ICAM1 p.K56M HFpEF Risk Variant.
СтатьяНазвание и аннотация: Перевод в очереди
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Giro Pedro, Filipp Mallory, Zhang Michael J, Moser Ethan D, Thorp Edward B, Dalal Prarthana J, Shah Ravi V, Ellinor Patrick T, Cunningham Jonathan W, Jurgens Sean J, Sinha Arjun, Rasmussen-Torvik Laura, Kizer Jorge, Taylor Kent D, Greenland Philip, Psaty Bruce M, Tracy Russell P, Chen Lin Yee, Shah Amil M, Yu Bing, Shah Sanjiv J, Patel Ravi B
Аннотация
A common missense variant in ICAM1 among African American individuals (rs5491; pK56M) has been associated with risk of heart failure with preserved ejection fraction (HFpEF), but the pathways that lead to HFpEF among those with this variant are not clear. In this analysis of 92 circulating proteins and their associated networks, we identified 7 circulating inflammatory proteins associated with rs5491 among >600 African American individuals. Using weighted coexpression network analysis, 3 protein networks were identified, one of which was associated with rs5491. This protein network was most highly represented by members of the tumor necrosis receptor superfamily. The rs5491 variant demonstrated an inflammatory proteomic profile in a separate cohort of African American individuals. This analysis identifies inflammatory pathways that may drive HFpEF among African American individuals with the ICAM1 pK56M (rs5491) variant.