Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2024
Metallic nanoparticles and treatment of cutaneous leishmaniasis: A systematic review.
Систематический обзорСтатьяНазвание и аннотация: Перевод в очереди
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Guerra Rhanoica Oliveira, do Carmo Neto José Rodrigues, da Silva Priscilla Elias Ferreira, Franco Pablo Igor Ribeiro, Barbosa Rafaela Miranda, de Albuquerque Martins Tarcísio, Costa-Madeira Juliana, de Assunção Thais Soares Farnesi, de Oliveira Carlo José Freire, Machado Juliana Reis, Silva Teixeira Luciana de Almeida, Rodrigues Wellington Francisco, Júnior Virmondes Rodrigues, Silva Anielle Christine Almeida, da Silva Marcos Vinicius
Аннотация
BACKGROUND: Cutaneous leishmaniasis (LC) is an infectious vector-borne disease caused by parasites belonging to the genus Leishmania. Metallic nanoparticles (MNPs) have been investigated as alternatives for the treatment of LC owing to their small size and high surface area. Here, we aimed to evaluate the effect of MNPs in the treatment of LC through experimental, in vitro and in vivo investigations.
METHODS: The databases used were MEDLINE/ PubMed, Scopus, Web of Science, Embase, and Science Direct. Manual searches of the reference lists of the included studies and grey literature were also performed. English language and experimental in vitro and in vivo studies using different Leishmania species, both related to MNP treatment, were included. This study was registered in PROSPERO (CRD42021248245).
RESULTS: A total of 93 articles were included. Silver nanoparticles are the most studied MNPs, and L. tropica is the most studied species. Among the mechanisms of action of MNPs in vitro, we highlight the production of reactive oxygen species, direct contact of MNPs with the biomolecules of the parasite, and release of metal ions.
CONCLUSION: MNPs may be considered a promising alternative for the treatment of LC, but further studies are needed to define their efficacy and safety.
METHODS: The databases used were MEDLINE/ PubMed, Scopus, Web of Science, Embase, and Science Direct. Manual searches of the reference lists of the included studies and grey literature were also performed. English language and experimental in vitro and in vivo studies using different Leishmania species, both related to MNP treatment, were included. This study was registered in PROSPERO (CRD42021248245).
RESULTS: A total of 93 articles were included. Silver nanoparticles are the most studied MNPs, and L. tropica is the most studied species. Among the mechanisms of action of MNPs in vitro, we highlight the production of reactive oxygen species, direct contact of MNPs with the biomolecules of the parasite, and release of metal ions.
CONCLUSION: MNPs may be considered a promising alternative for the treatment of LC, but further studies are needed to define their efficacy and safety.