Bioinformatics (Oxford, England) · 2010
Bayesian ensemble methods for survival prediction in gene expression data.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАПоддержка правительства СШАНазвание и аннотация: Перевод в очереди
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Bonato Vinicius, Baladandayuthapani Veerabhadran, Broom Bradley M, Sulman Erik P, Aldape Kenneth D, Do Kim-Anh
Аннотация
MOTIVATION: We propose a Bayesian ensemble method for survival prediction in high-dimensional gene expression data. We specify a fully Bayesian hierarchical approach based on an ensemble 'sum-of-trees' model and illustrate our method using three popular survival models. Our non-parametric method incorporates both additive and interaction effects between genes, which results in high predictive accuracy compared with other methods. In addition, our method provides model-free variable selection of important prognostic markers based on controlling the false discovery rates; thus providing a unified procedure to select relevant genes and predict survivor functions.
RESULTS: We assess the performance of our method several simulated and real microarray datasets. We show that our method selects genes potentially related to the development of the disease as well as yields predictive performance that is very competitive to many other existing methods.
AVAILABILITY: http://works.bepress.com/veera/1/.
RESULTS: We assess the performance of our method several simulated and real microarray datasets. We show that our method selects genes potentially related to the development of the disease as well as yields predictive performance that is very competitive to many other existing methods.
AVAILABILITY: http://works.bepress.com/veera/1/.