Temporary liver support using a new type of sorbent. A urethane sheet embedded with powdered charcoal.

A new sorbent, urethane sheet embedded with powdered charcoal (UPC, BESPORE), which had been developed for use in a temporary liver support system, has been clinically applied since 1984. This system consists of a UPC plasma-perfusion circuit (using a recirculation system) followed by a supplementary 0.8 L plasma exchange, using hemodialysis for the purpose of performing both removal and supplementary therapy at the same time. On average, approximately 40% of both bilirubin and bile acid are removed, with the osmolality gap reduced by 30%. This system is effective for prolongation of life in patients with chronic hepatic failure and those with acute hepatic failure that has become chronic. It can be considered an effective maintenance therapy for patients before liver transplantation.