Current issues in molecular biology · 2025
IL-4 and Brentuximab Vedotin in Mycosis Fungoides: A Perspective on Potential Therapeutic Interactions and Future Research Directions.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
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Andreescu Mihaela, Tudorache Sorin Ioan, Moldovan Cosmin Alec, Andreescu Bogdan
Аннотация
BACKGROUND: Mycosis fungoides (MF), the most prevalent cutaneous T cell lymphoma, features clonal CD4⁺ T cell proliferation within a Th2-dominant microenvironment. Interleukin-4 (IL-4) promotes disease progression while Brentuximab Vedotin (BV), an anti-CD30 antibody-drug conjugate, shows efficacy but faces resistance challenges.
METHODS: We conducted a narrative literature review (2010-2024) synthesizing evidence on IL-4 signaling and BV's efficacy in MF to develop a theoretical framework for combination therapy.
RESULTS: IL-4 may modulate CD30 expression and compromise BV's effectiveness through immunosuppressive microenvironment remodeling. Theoretical mechanisms suggest that IL-4 pathway inhibition could reprogram the microenvironment toward Th1 dominance and restore BV sensitivity. However, no direct experimental evidence validates this combination, and safety concerns including potential disease acceleration require careful evaluation.
CONCLUSIONS: The proposed IL-4/BV combination represents a biologically compelling but unproven hypothesis requiring systematic preclinical validation and biomarker-driven clinical trials. This framework could guide future research toward transforming treatment approaches for CD30-positive MF by targeting both malignant cells and their immunologically permissive microenvironment.
METHODS: We conducted a narrative literature review (2010-2024) synthesizing evidence on IL-4 signaling and BV's efficacy in MF to develop a theoretical framework for combination therapy.
RESULTS: IL-4 may modulate CD30 expression and compromise BV's effectiveness through immunosuppressive microenvironment remodeling. Theoretical mechanisms suggest that IL-4 pathway inhibition could reprogram the microenvironment toward Th1 dominance and restore BV sensitivity. However, no direct experimental evidence validates this combination, and safety concerns including potential disease acceleration require careful evaluation.
CONCLUSIONS: The proposed IL-4/BV combination represents a biologically compelling but unproven hypothesis requiring systematic preclinical validation and biomarker-driven clinical trials. This framework could guide future research toward transforming treatment approaches for CD30-positive MF by targeting both malignant cells and their immunologically permissive microenvironment.