Clinical lymphoma, myeloma & leukemia · 2026
Olverembatinib-Based Therapy in Patients With Transformed Chronic Myeloid Leukemia in Lymphoid Blast Phase or Relapsed or Refractory Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: A Multicenter Retrospective Study.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
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Bao Mei, Huang Jian, Li Zongru, Chen Chunyan, Yang Linhua, Ma Yanping, Zhang Yanli, Meng Li, Liu Zhenfang, Wen Qin, Chen Suning, Yang Xiaofei, Yi Hai, Lin Congmeng, Song Yang, Jiang Qian
Аннотация
OBJECTIVES: To explore the efficacy and safety olverembatinib-based therapy in patients with transformed chronic myeloid leukemia in lymphoid blast phase (CML-LBP) or relapsed or refractory Philadelphia chromosome-positive acute lymphoblastic leukemia (R/R Ph+ ALL).
METHODS: Data of patients with transformed CML-LBP or R/R Ph+ ALL receiving olverembatinib-based therapy from 24 academic centers in China were retrospectively interrogated. Cox regression model was utilized to identify covariates associated with survival.
RESULTS: 75 patients with transformed CML-LBP (n = 26, 35%) and R/R Ph+ ALL (n = 49, 65%) were enrolled in this study. Median age was 51 years old (interquartile range [IQR], 40-57 years). With a median follow-up of 18 months (IQR, 11-27 months), excluding 1 patient with early death, 58 patients (78%) achieved complete remission/complete remission with incomplete hematologic recovery by 28 days. The 2-year probability of overall survival was 43% (95% Confidence Interval [CI], 29-56%) with median overall survival of 18 months (95% CI, 7-29 months). The therapy was well-tolerated. In multivariate analyses, higher hemoglobin concentration (Hazard ratio [HR] = 0.9 [0.7, 1.0], P = .049) and receiving a transplant (HR = 0.2 [0.1, 0.5], P = .001) were significantly-associated with better survival.
CONCLUSIONS: Olverembatinib-based therapy is effective and tolerable in patients with transformed CML-LBP and R/R Ph+ ALL.
METHODS: Data of patients with transformed CML-LBP or R/R Ph+ ALL receiving olverembatinib-based therapy from 24 academic centers in China were retrospectively interrogated. Cox regression model was utilized to identify covariates associated with survival.
RESULTS: 75 patients with transformed CML-LBP (n = 26, 35%) and R/R Ph+ ALL (n = 49, 65%) were enrolled in this study. Median age was 51 years old (interquartile range [IQR], 40-57 years). With a median follow-up of 18 months (IQR, 11-27 months), excluding 1 patient with early death, 58 patients (78%) achieved complete remission/complete remission with incomplete hematologic recovery by 28 days. The 2-year probability of overall survival was 43% (95% Confidence Interval [CI], 29-56%) with median overall survival of 18 months (95% CI, 7-29 months). The therapy was well-tolerated. In multivariate analyses, higher hemoglobin concentration (Hazard ratio [HR] = 0.9 [0.7, 1.0], P = .049) and receiving a transplant (HR = 0.2 [0.1, 0.5], P = .001) were significantly-associated with better survival.
CONCLUSIONS: Olverembatinib-based therapy is effective and tolerable in patients with transformed CML-LBP and R/R Ph+ ALL.