Risk factors for incident type 2 diabetes among adults with impaired fasting glucose: a comparison of three regression models accounting for competing mortality in Liuzhou, Guangxi, China.

OBJECTIVES

Impaired fasting glucose (IFG) is a prediabetic precursor of type 2 diabetes (T2DM). Few long-term cohorts with substantial competing mortality compare risk estimates from logistic, Cox and Fine-Gray regression. This study aimed to examine cross-model discrepancies and demonstrate model-dependent bias in IFG risk inference.

METHODS

We followed 913 Chinese IFG adults recruited in Liuzhou, Guangxi (2004-2008) for up to 20 years until 31 December 2024 (median 17.83 years). Three regression models were used to identify fully adjusted T2DM predictors.

RESULTS

Fasting glucose, body fat percentage and older age were consistent positive predictors; female sex was persistently protective. Body mass index (BMI) ≥28 kg/m2 and waist-to-hip ratio showed divergent results across models. Hypertension lacked independent effects in all models, and enrollment year was significant only in Cox regression.

CONCLUSIONS

Statistical model choice alters risk factor conclusions in IFG cohorts with high competing mortality. Joint interpretation of complementary regression methods is recommended.