Leukemia research · 2014
Chronic kidney disease in patients with the Philadelphia-negative chronic myeloproliferative neoplasms.
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Christensen Alexander Sidelmann, Møller Jonas Bech, Hasselbalch Hans Carl
Аннотация
BACKGROUND: The progression of kidney function and frequency of chronic kidney disease (CKD) in patients with the Philadelphia-negative myeloproliferative neoplasms (MPN) is unknown, although CKD is linked to increased mortality.
METHODS: This longitudinal retrospective study evaluates the estimated glomerular filtration rate (eGFR) in 143 MPN patients over a period of 9 years.
RESULTS: 29% of patients had CKD stage 3 or 4 at time of diagnosis. 20% of patients had a rapid annual loss of eGFR (>3mL/min/1.73m(2)) and eGFR was negatively correlated to monocyte and neutrophil counts.
CONCLUSION: Kidney impairment might contribute to the increased mortality observed in MPN patients.
METHODS: This longitudinal retrospective study evaluates the estimated glomerular filtration rate (eGFR) in 143 MPN patients over a period of 9 years.
RESULTS: 29% of patients had CKD stage 3 or 4 at time of diagnosis. 20% of patients had a rapid annual loss of eGFR (>3mL/min/1.73m(2)) and eGFR was negatively correlated to monocyte and neutrophil counts.
CONCLUSION: Kidney impairment might contribute to the increased mortality observed in MPN patients.