EJHaem · 2026
Prevalence of Low Bone Mineral Density Increases With Age in Sickle Cell Disease.
СтатьяНазвание и аннотация: Перевод в очереди
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Gollamudi Jahnavi, Wu Chengzhou, Kang Guolian, Lamonica Michael Sexton, Chen Pei-Lin, Srinivasan Ragha, El-Bashir Khalid, Hankins Jane, Rai Parul, Takemoto Clifford, Hyacinth Hyacinth I, Allen Matthew R, Zemel Babette S, Adesina Oyebimpe
Аннотация
INTRODUCTION: Skeletal complications are common in sickle cell disease (SCD). We previously showed that the prevalence of low areal bone mineral density (aBMD) increased with age in a pediatric SCD cohort, even after adjusting for short stature. Data on age-related aBMD trends in young adults is lacking.
METHODS: Using retrospective data from the Sickle Cell Clinical Research and Intervention Program (SCCRIP), we converted lumbar spine (LS) and total body (TB) aBMD from 713 SCCRIP participants (49.2% females, ages 6-24 years) to age-, sex-, ancestry-, and height-adjusted Z-scores, using data from healthy African American controls enrolled in the Bone Mineral Density in Childhood Study.
RESULTS: Low TB bone density prevalence rates increased with age: 29.5% in children (6-< 12 years), 36.7% in adolescents (12-< 18 years), and 42.2% in young adults (18-24 years). LS aBMD followed a similar age-related trend. Multivariable analysis revealed older age (OR 1.10, 95% CI 1.06-1.16), lower hemoglobin (OR 0.833, 95% CI 0.740-0.936), and higher eGFR (OR 1.01, 95% CI 1.00-1.02) as independent predictors for low TB BMD.
CONCLUSION: These findings highlight the progressive decline of aBMD in SCD and underscore the need for early screening to mitigate morbidity due to SCD-related skeletal complications. Trial Registration: The authors have confirmed clinical trial registration is not needed for this submission.
METHODS: Using retrospective data from the Sickle Cell Clinical Research and Intervention Program (SCCRIP), we converted lumbar spine (LS) and total body (TB) aBMD from 713 SCCRIP participants (49.2% females, ages 6-24 years) to age-, sex-, ancestry-, and height-adjusted Z-scores, using data from healthy African American controls enrolled in the Bone Mineral Density in Childhood Study.
RESULTS: Low TB bone density prevalence rates increased with age: 29.5% in children (6-< 12 years), 36.7% in adolescents (12-< 18 years), and 42.2% in young adults (18-24 years). LS aBMD followed a similar age-related trend. Multivariable analysis revealed older age (OR 1.10, 95% CI 1.06-1.16), lower hemoglobin (OR 0.833, 95% CI 0.740-0.936), and higher eGFR (OR 1.01, 95% CI 1.00-1.02) as independent predictors for low TB BMD.
CONCLUSION: These findings highlight the progressive decline of aBMD in SCD and underscore the need for early screening to mitigate morbidity due to SCD-related skeletal complications. Trial Registration: The authors have confirmed clinical trial registration is not needed for this submission.