Meningoencephalitis with Aspergillus and mycobacterium tuberculosis in a renal transplant recipient.

OBJECTIVES

We report a case of central nervous system coinfection with 2 types of opportunistic organisms-Aspergillus and Mycobacterium tuberculosis-in a 33-year-old woman who underwent a renal transplant.

MATERIALS AND

METHODS

She developed a high-grade fever and right-sided weakness 1 month after the transplant while on mycophenolate mofetil, prednisolone, and cyclosporine.

RESULTS

Brain magnetic resonance imaging revealed multiple mass lesions with peripheral ring enhancement. Colony-stimulating factor polymerase chain reaction was positive for Aspergillus and Mycobacterium tuberculosis.

CONCLUSIONS

Broad-spectrum antibiotics, antituberculous agents, and amphotericin were started. Unfortunately, the woman's condition deteriorated, and she died 2 weeks after admission to the hospital.