[Relation of risk factors to coronary artery stenosis severity in coronary atherosclerotic heart disease].

OBJECTIVE

To study the relationship of the risk factors to the coronary artery stenosis severity in coronary atherosclerotic heart disease (CAD).

METHODS

286 CAD patients, 206 males and 80 females, aged 61.6, underwent coronary angiography and then were divided into 3 groups according to its results: Group A with single vessel lesion, Group B with double vessel lesions, and Group C with triple/left main vessel lesions. Peripheral blood samples were collected to measure the levels of uric acid, C reactive protein, cholesterol, low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol, and triglyceride. Spearman correlation analysis and multiple linear regression were used to analyze the relationship between the risk factors including age, bodyweight, and blood lipids and uric acid.

RESULTS

There was significant difference among the three groups at age and LDL-C (both P < 0.05). Age and LDL-C of Group C [(62 +/- 10), (3.0 +/- 0.7) mmol/L] were significantly higher than those of Group A [(59 +/- 11), (2.8 +/- 0.6) mmol/L, both P < 0.05]. Age (r = 0.163) and LDL-C (r = 0.149) were significantly associated with coronary artery stenosis severity (both P < 0. 05).

CONCLUSION

The severity of coronary artery stenosis is affected by age and LDL-C. Triple/left main vessel lesions are likely to be seen in the patients with older age and higher blood level of LDL-C.