Serum Biochemistry and Histopathological Profiles of Normoglycemic and Streptozotozin-Induced Hyperglycemic Rats Treated with Mace Water Extract from Myristica fragrans Houtt.

Background/

Objectives

This in vivo study was conducted to investigate the effects of mace water extract from Myristica fragrans Houtt (ME) on serum biochemical and histopathological profiles of normoglycemic and streptozotozin-induced hyperglycemic rats.

Methods

Biochemical parameters (cholesterol, HDL, LDL, triglycerides, creatinine, blood urea nitrogen, AST, ALT, and albumin) from all groups of experimental rats were analyzed. Histopathological analysis was also performed on the kidney, liver, and pancreatic tissues.

Results

The results showed that administration of ME (1.84 mg total phenolics from ME/kg BW) was able to prevent serum biochemical changes that are indicators of metabolic disorders and organ tissue damage due to hyperglycemia. ME significantly reduced LDL (31.85%), creatinine (13.78%), AST (58.97%), and ALT (60.04%) levels in hyperglycemic rats. ME also showed promising performance in protecting the kidney and liver from damage due to hyperglycemia.

Conclusions

The findings in this study emphasize the potential of ME to be used as a therapeutic agent and functional ingredient.