The role of neurogenesis in neurodegenerative diseases: Mechanisms and interventions.

Neurogenesis is the process by which new neurons are generated from neural stem cells (NSCs) and neural progenitor cells (NPCs). Impairment in this process can lead to cognitive and memory deficits, among other issues. Research indicates that defective neurogenesis is closely associated with neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD). These conditions not only affect a significant global population but also exert profound societal and economic impacts. However, the precise mechanisms underlying neurodegenerative diseases remain incompletely understood, and the relationship between neurogenesis and these disorders requires further exploration. This review examines the role of neurogenesis in major neurodegenerative diseases, emphasizing the importance of early diagnosis and precision therapy. The findings aim to provide a foundation for developing novel treatments, thereby alleviating the burden on patients and their families.