Trends in mortality involving co-reported arrhythmia and dyslipidemia, 1999-2023: A Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research analysis with exploratory projections to 2035.

ObjectiveEmerging evidence links dyslipidemia to cardiac structural and electrical remodeling. This study examined national trends in mortality involving co-reported arrhythmia and dyslipidemia among US adults aged ≥65 years from 1999 to 2023 and provided exploratory projections through 2035.MethodsThis retrospective, observational, population-based study used death-certificate data from the Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research multiple-cause mortality database. Deaths among adults aged ≥65 years listing arrhythmia (International Classification of Diseases and Related Health Problems, 10th revision: I44.0-I44.7, I45.0-I45.9, I47.0-I47.9, I48, and I49.0-I49.9) and dyslipidemia (E78) among multiple causes were included. Age-adjusted mortality rates per 100,000 were calculated and stratified by sex, race/ethnicity, census region, and urban-rural status. Joinpoint regression was used to calculate annual percentage changes. An exploratory autoregressive integrated moving average model projected rates through 2035.ResultsA total of 246,710 deaths involving co-reported arrhythmia and dyslipidemia occurred between 1999 and 2023. The age-adjusted mortality rate increased from 4.96 (1999) to 47.9 (2023) per 100,000. The largest increase occurred between 2018 and 2021 (annual percentage change: 17.88%; 95% confidence interval: 14.79 to 21.04). An exploratory autoregressive integrated moving average model projected the age-adjusted mortality rate to reach 68.54 (95% prediction interval: 49.85-87.24) by 2035. Higher rates were observed in males, non-Hispanic White individuals, South and West regions, and nonmetropolitan areas.ConclusionsMortality involving co-reported arrhythmia and dyslipidemia among older US adults increased substantially over 25 years with persistent demographic and geographic disparities. These findings highlight the need for continued surveillance and research into contributing factors.