Irish journal of medical science · 2025
Intestinal fatty-acid binding protein as a diagnosis marker in younger with celiac diseases.
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Taha Ali A, Khalil Shaimaa Ibrahim, Al-Azzawi Ammar M K, Hassan Ekhlas Abdallah
Аннотация
BACKGROUND: Celiac disease (CD) is an autoimmune disorder known to be highly associated with autoimmune manifestations and genetic factors. The aim of this paper was to assess the diagnostic accuracy of serum I-FABP in CD patients.
METHODS: Fifty patients with CD were classified into two groups: (30) exhibiting positive titers of tTG-IgA test and tTG-IgG test value more than 18 AU/mL and (20) patients with a potential diagnosis of CD (equivocal titers of IgG and IgA tTG 12-18 AU/mL) for comparison, as well as 50 healthy individuals were included as a control. The ELISA Kit was used to measure serum I-FABP where serum iron and serum ferritin were measured through the standard methods on the Smart-150 autoanalyzer biochemistry, instead of IgG and IgA tTG that was determined using an immunoenzymatically technique.
RESULTS: The concentration of serum I-FABP in the CD group was significantly higher than that of the healthy subjects (p < 0.05). There was a significant difference in the serum I-FABP concentrations between two patients. There were substantial positive connections between serum 1-FAPB concentration and IgG, as well as strong positivity correlations between serum 1-FAPB and serum IgA Ttg in CD patients. The concentration of serum 1-FAPB, on the other hand, had no significant association with the anti Ttg IgG and serum IgA Ttg. The area under the curve was excellent (AUC = 1, p = 0.0001), with high diagnostic accuracy (96.2) in differentiating CD from the healthy subject group.
CONCLUSION: I-FABP levels in the sera of were shown to be higher and I-FABP levels were shown to be significantly linked between activated immune response (IgA-tTG) and enterocyte damage (I-FABP) in CD patients.
METHODS: Fifty patients with CD were classified into two groups: (30) exhibiting positive titers of tTG-IgA test and tTG-IgG test value more than 18 AU/mL and (20) patients with a potential diagnosis of CD (equivocal titers of IgG and IgA tTG 12-18 AU/mL) for comparison, as well as 50 healthy individuals were included as a control. The ELISA Kit was used to measure serum I-FABP where serum iron and serum ferritin were measured through the standard methods on the Smart-150 autoanalyzer biochemistry, instead of IgG and IgA tTG that was determined using an immunoenzymatically technique.
RESULTS: The concentration of serum I-FABP in the CD group was significantly higher than that of the healthy subjects (p < 0.05). There was a significant difference in the serum I-FABP concentrations between two patients. There were substantial positive connections between serum 1-FAPB concentration and IgG, as well as strong positivity correlations between serum 1-FAPB and serum IgA Ttg in CD patients. The concentration of serum 1-FAPB, on the other hand, had no significant association with the anti Ttg IgG and serum IgA Ttg. The area under the curve was excellent (AUC = 1, p = 0.0001), with high diagnostic accuracy (96.2) in differentiating CD from the healthy subject group.
CONCLUSION: I-FABP levels in the sera of were shown to be higher and I-FABP levels were shown to be significantly linked between activated immune response (IgA-tTG) and enterocyte damage (I-FABP) in CD patients.